Inhibitory Avoidance Training
behavioral task is conducted by first placing the subject in the brightly-illuminated
white compartment facing the sliding guillotine door. After the
subject turns in the opposite direction, the door is lowered into the
floor allowing free access to the darker compartment of the apparatus.
When the subject rotates again and faces the open door, a timer is started
and the latency to completely enter the dark compartment is recorded.
Upon entering the dark compartment, the sliding door is raised and a footshockis
administered (from 0.35 to 0.45 mA, for 0.5 or 1 second). Immediately
after the footshock training, the subject is removed from the apparatus
and administered a pharmacological treatment either systemically or directly
into a specific brain structure.