Our research group employs experimental and theoretical engineering approaches to investigate chromatographic separation problems and develop new materials and processes for bioseparation applications. We are especially interested in studying the relationship between adsorbent characteristics, biomolecular structure, and mass transfer and in the optimization of process chromatography for the recovery, separation, and purification of biomolecules. Our current projects are sponsored by: Ajinomoto, Bio-Rad Laboratories, MedImmune, Merck & Co., Inc., Pfizer, and Bristol-Myers Squibb.

WELCOME TO THE BIOSEPARATIONS ENGINEERING LABORATORY AT UVA

NEWS

This site is maintained by: Preston Fuks

For questions or comments about this site, contact pefzd@virginia.edu

  1. PREP2018 - 31st International Symposium on Preparative and Process Chromatography will be held in Baltimore, MD, on July 8-11, 2018 at the Hyatt Regency Baltimore Inner Harbor Hotel, chaired by Prof. Giorgio Carta, under the auspices of the University of Virginia. www.prepsymposium.org. The entire group will attend thanks to the generosity of the PREP2018 corporate sponsors.

  1. SEAS Open House - The Carta Lab participated in the SEAS Open House held on March 19, 2016 with an exhibit on the use of chromatography for the purification of biotherapeutics. Yiran Wang also took a break from her own research and conducted a live protein chromatography demonstration which illustrated the separation of a mixture of three proteins by gradient elution. About 100 people visited our lab and learned about what we do and watched bands of colored proteins move through, spread, and become separated. Thanks to Yiran for organizing and conducting an informative demo.

  1. New Home for the Carta Lab - After more than 20 years in the basement of Thornton Hall A-Wing, the Bioseparations Engineering Laboratory has moved to renovated space in the Chemical Engineering Building. The new space provides a greatly improved research environment, as well as high-quality graduate student office space. We have also acquired new equipment, including four ÄKTA Pure 25 systems, a Waters UHPLC, and a biolayer interferometry instrument. The move was completed in January 2016.

  1. Short Course - The Carta Lab will offer its next Short Course in Protein Chromatography on May 13-18, 2018. The course is attended primarily by industry professionals who spend a week with us to learn about engineering fundamentals and measurements for process development and design. This is also a great opportunity to share the results of our research and facilitate translation of our fundamental work to industrial practice. Please see the “Short Course” tab above or http://faculty.virginia.edu/shortcourse/HomePage.html.

  1. SPICA 2016 - Prof. Carta is an invited keynote speaker at the 16th International Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA) to be held in Vienna, Austria - October 9-12, 2016. He will present recent work from the lab dealing with unfolding and aggregation of proteins in chromatography columns. See http://www.ldorganisation.com/v2/produits.php?langue=english&cle_menus=1238916108&cle_data=1360153443&output=16

  1. Annual DuPont Safety Award - Arch Creasy was awarded the inaugural Annual DuPont Safety Award for 2016. Arch instituted numerous safety features into the new lab space in ChE using 6S principles he acquired during his internship. Some of the changes include: tubing from the AKTAs, HPLC, and UPLC going directly to waste bins, new magnetic labels for all drawers and cabinet space, ,and standardized techniques for disposing of filled waste containers. Congratulations Arch.

Arch Creasy (center) along with Prof. Gary Koenig (left), chair of the UVA ChE Safety Committee, and Dave Reichert (right) of DuPont

  1. SEAS Open House - The Carta Lab participated again in the SEAS Open House held on March 18, 2017 with an exhibit on the use of chromatography for the purification of biotherapeutics. Lucas Kimerer and Yiran Wang took a break from their research and conducted a live protein chromatography demonstration which illustrated the separation of a mixture of three proteins by gradient elution. About 100 people visited our lab and learned about what we do and watched bands of colored proteins move through, spread, and become separated. Thanks to Lucas and Yiran for organizing and conducting an informative demo.

  1. Giorgio Carta interview on Challenges and Opportunities for Improved Chromatography Resins at BPI Boston, 2007. Watch the full interview at the following link: 

https://www.youtube.com/watch?v=g1BgRVa32EE

  1. Alumnus Shaojie Zhang (PhD 16’) was selected as a finalist for the 2017 MilliporeSigma Life Science Award in Bioseparations. Shaojie was selected for his research in our group dealing with protein adsorption in Protein A and AEX resins in relationship to resin fouling and weak partitioning chromatography. He will present his research at the MilliporeSigma facility in Burlington, MA on October 18th. We congratulate Shaojie for this great honor.

  1. Giorgio Carta presented an invited talk entitled "Mechanistic Understanding and Modeling to Predict and Optimize Aggregate Clearance from Monoclonal Antibodies by Ion Exchange Chromatography” at the 5th Annual Biologics Manufacturing Asia 2018 at the Suntec Singapore Exhibition and Convention Centre.

  1. Zhu, Mimi, Preston Fuks, and Giorgio Carta. "Protein adsorption in anion exchange resins–effects of polymer grafting, support structure porosity, and protein size." is featured on the cover of the Journal of Chemical Technology and Biotechnology, Volume 93, Issue 7.
    https://onlinelibrary.wiley.com/toc/10974660/2018/93/7

  1. Protein Chromatography: Process Development and Scale-Up, to order a copy go to the link: http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527318194.html












  1. Perry’s Handbook 9th Edition Giorgio Carta and ChE alumnus M. Douglas LeVan (BS`71) , J. Lawrence Wilson Professor Emeritus, Vanderbilt University, coedit Section 16 – Adsorption & Ion Exchange of Perry's Chemical Engineers' Handbook, 9th Edition published on August 8, 2018. Perry’s Handbook, published by McGraw-Hill, is widely recognized as the most authoritative handbook reference for chemical engineering professionals, researchers, and students. Section 16, extensively revised and including contributions from James Ritter, University of South Carolina, and Krista Walton, Georgia Tech, provides an in-depth coverage of the theory and practice of adsorption and ion exchange materials and processes, critical in many applications including the production of chemicals, pharmaceuticals, and energy as well as environmental protection [https://www.mhprofessional.com/9780071834087-usa-perrys-chemical-engineers-handbook-9th-edition].

  1. PREP2019 - 32nd International Symposium on Preparative and Process Chromatography will be held in Baltimore, MD, on July 7-10, 2019 at the Hyatt Regency Baltimore Inner Harbor Hotel, chaired by Prof. Giorgio Carta, under the auspices of the University of Virginia. www.prepsymposium.org. The entire group will attend thanks to the generosity of the PREP2019 corporate sponsors. Post the attached under the script above.

  1. Arch Creasy (PhD `2018) was selected for a "The Best of BIOT Award”. The Best of BIOT awards are the ACS BIOT Division annual recognition of excellent presentations given at the spring ACS National Meeting. The winners are selected based on audience and session chair voting. Each recipient is invited to give a webinar reprising the original presentation and the award talks from the same scientific area are given on the same day. In an effort to promote scientific discourse and connectivity throughout the BIOT community.

  1. Lucas Kimerer received the Georges Guiochon Chromatography Award for the best poster at the 2018 Washington Chromatography Discussion Group Poster Session & Vendor Exhibition held in Bethesda, Maryland on September 19. 2018. The award includes a  travel grant to attend the HPLC 2019 conference in Milan, Italy.