The Giri research group is focused on studying the fundamental processes (thermodynamic, kinetic, mechanical and optical) that lead to different organic molecule and metal organic framework morphologies, and utilizing this knowledge to create innovative methods of controlling microstructure and phase for pharmaceutical and energy applications. Microfluidics and X-ray diffraction analysis methods feature strongly in our program to study organic molecule packing and morphology.

We are located in the Department of Chemical Engineering at the University of Virginia.

giri group members
giri group members
giri group members

Pharmaceutical polymorphism for physiochemical testing

Ismagilov et. al.

Biological availability of a pharmaceutical compound is highly dependent on the solid phase structure of the compound, as well as the crystal size and crystal size distribution. Our group is constructing a microfluidic program that can generate varying crystal structures and sizes of potential pharmaceutical compounds in-flow. These structures can be easily handled and transported to different regions to test their physical and biological properties. Our goal is to create a rapid integrated microfluidic process that generates the crystal structures/sizes and tests the physical and biological properties of candidate pharmaceutical molecules without using a lot of material or taking a long time.

Understanding phase transformation of small molecules for organic electronics


In organic electronics, the exact crystal packing, disorder and defect can dramatically change the charge transport properties of the resulting devices. There is currently incomplete understanding of the crystal packing phase space that is possible for high performance organic semiconductors. We are using microfluidics and x-ray diffraction is used to create methods to generate complete thermodynamic and kinetic phase diagrams for small organic molecules rapidly and without the use of large amounts of material. We apply this understanding to create high performance organic electronics. This data will also be invaluable in testing hypotheses of the relationship between a compound’s chemical structure and its physical micro/macrostructure. This knowledge is applicable to organic semiconductors and nanoparticles.

Harnessing Metal Organic Framework (MOF) crystal growth for electronic and chemical application


Metal organic frameworks are an emerging class of materials that show promise for various applications such as sensing, electronics and energy storage. Using crystal growth understanding, our group is exploring MOF crystallization, polymorphism and thin film formation. We are also studying the sensitivity and stability of MOFs for sensing, catalysis, storage, separation and electronics.

giri group members 1
giri group members 2

About the Giri Group

The Giri Group is a wonderful place to work! We focus on working hard, having fun, and promoting a safe and happy work environment. Check out more about our lab with the links below.

Meet our Team! Contact Us!

Recent News & Publications

Luke is working to harness the power of metal organic frameworks to improve the environment and improve air quality.
Luke and Stephanie have received the degree Master of Science in Chemical Engineering, December 2017!
The Giri Group is excited to welcome graduate students Ashley Conley and Steve Jung and undergraduate researchers Rachel Ho, Max Pan, John Choi, Nicholas Blackwell and Karl Westendorff.
Stephanie will present her work titled:"Polymorphism in Drug Compounds By Controlling Fluid Dynamics during Crystallization", and Arian will present his work titled: "Closed Packed, Oriented MOF Thin Films through Solution Shearing"
Professor Giri was granted the VSGC New Investigator Award for his proposal: Lightweight Metal Organic Framework Thin Films for Flexible Electronics and Fuel Cells. Congratulations Professor Giri!
The Jeffress Trust Program will support a one-year pilot study to support our group's interdisciplinary work with Professor Baoxing Xu.
With the addition of a glovebox and BET Machine, a large portion of the lab equipment is set up and running. Check out our Facilities Page to see the other equipment in our lab.
The Giri Group is excited to welcome three new undergraduate researchers: John Choi, Max Pan, and Nicholas Blackwell. All three are great additions to the lab and we are very excited to have them. Welcome!
Giri Group travels to the Cornell High Energy Synchotron Source (CHESS).
Stephanie attended and presented her work at the the Biotechnology Training Program Symposium on November 10th and received 2nd place for her poster presentation. Congratulations, Stephanie!
Nan attended and presented his work at the 83rd Annual Meeting of the American Physical Society Southeastern Section. His abstract can be found here.
Arian attended and presented his work at the 83rd Annual Meeting of the American Physical Society Southeastern Section. His abstract can be found here.
Nan attended and presented his work at the Virginia Soft Matter Workshop at Virginia Commonwealth University on October 29th. Congratulations, Nan!
Stephanie and Nan passed the qualifying exam to officially become PhD candidates. Congratulations!
Arian received is PhD from the University of Houston for his work with zeolite catalysts. We are excited to have him join the group. Welcome, Arian!
We are excited to have him join the group. Welcome, Luke!
Giri Group travels to the Cornell High Energy Synchotron Source (CHESS) with the Choi Group.
Stephanie was awarded the Graduate STEM Research Fellowship with the Virginia Space Grant Consortium, a program designed to encourage and support the future leaders of STEM, especially in those topics related to NASA and its missions.