Molecular Biomechanics Laboratory

Peer-Reviewed Journal Articles

Crissman, R.S. and W.H. Guilford (1984) "The Three-Dimensional Architecture of the Elastic Fiber Network in Canine Hepatic Portal System." American Journal of Anatomy 171: 401-13.

Grdina, D.J., W.H. Guilford, C.P. Sigdestad and C.S. Giometti (1988) “Effects of Radioprotectors on DNA Damage and Repair, Proteins, and Cell-cycle Progression.” Pharmacology and Therapeutics 39: 133-7.

Sigdestad, C.P., W. Guilford, J. Perrin and D.J. Grdina (1988) “Cell Cycle Redistribution of Cultured Cells After Treatment With Chemical Radiation Protectors.” Cell and Tissue Kinetics 21(3): 193-200.

Guilford, W.H. R.W. Gore (1992) “A Novel, Remote-Sensing, Isometric Force Transducer for Micro-Mechanics Studies” American Journal of Physiology 263 (Cell Physiology 32): C700-707.

VanBuren, P., W.H. Guilford, G. Kennedy, J. Wu and D.M. Warshaw (1995) “Smooth Muscle Myosin: A High Force-Generating Molecular Motor” Biophysical Journal, 68: 256s-259s.

Guilford, W.H, R.W. Gore and R.C. Lantz (1995) “The locomotive forces produced by single leukocytes in vivo and in vitro” American Journal of Physiology, 268 (Cell Physiology 37): C1308-12 .

Guilford, W. H. and R.W. Gore (1995) “The Mechanics of Arteriolar-Tissue Interaction.” Microvascular Research, 50: 260-287.

Dupuis, D.E., W.H. Guilford, J. Wu and D.M. Warshaw (1996) “Actin Filament Mechanics in the Laser Trap” Journal of Muscle Research and Cell Motility, 18 (1): 17-30.

Guilford, W.H., D.E. Dupuis, G. Kennedy, J. Wu, J.B. Patlak and D.M. Warshaw (1997) “Smooth and Skeletal Muscle Myosins Produce Similar Unitary Forces and Displacements in the Laser Trap.” Biophysical Journal, 72 (3): 1006-21

Guilford, W.H. and D.M. Warshaw (1998) “The Molecular Mechanics of Smooth Muscle Myosin” Comparative Biochemistry and Physiology, Part B, 119: 451-58.

Tyska, M.J., D.E. Dupuis, W.H. Guilford, J.B. Patlak, G.S. Waller, K.M. Trybus, D.M. Warshaw, and S. Lowey (1999) “Two Heads of Myosin are Better than One for Generating Force and Motion” Proceedings of the National Academy of Sciences, 96: 4402-7.

Warshaw,D.M. W.H. Guilford, Y. Freyzon, E. Krementsova, K.A. Palmiter, M.J. Tyska, J.E. Baker, and K.M. Trybus (2000 “The Light Chain Binding Domain of Expressed Smooth Muscle Heavy Meromyosin Acts as a Mechanical Lever” Journal of Biological Chemistry, 275: 37167-37172.

Guilford, W.H. (2001) "Teaching Peer-review and the Process of Scientific Writing" Advances in Physiology Education, 25: 167-175.

Cheezum, M.K., W.F. Walker and W.H. Guilford (2001)"Quantitative comparison of algorithms for tracking single fluorescent particles." Biophysical Journal, 81: 2378-88.

Rinko, L.J., M.B. Lawrance and W.H. Guilford (2004) “The Molecular Mechanics of P- and L-selectin Lectin Domains Binding to PSGL-1” Biophysical Journal, 86: 544-54.

Guilford, W.H., J.A. Tournas, D. Dascalu, and D.S. Watson (2004) “Creating multiple, time-shared laser traps with simultaneous displacement detection using digital signal processing hardware.” Analytical Biochemistry, 326(2): 153-66.

Guo, B. and W.H. Guilford (2004) "The Tail of Myosin Reduces Actin Filament Velocity in the in vitro Motility Assay" Cell Motility and the Cytoskeleton, 59: 264-72.

Guilford, W.H. (2004) “Teaching Cell and Molecular Biology within the Context of Human Disease.” In press

Thesis / Book Chapters

Winfree, A.T. and W. Guilford (1988) "The Dynamics of Organizing Centers: Numerical Experiments in Differential Geometry." in Biomathematics and Related Computational Problems, ed. L.M. Ricciardi (Kluwer Academic Publishers), pp. 697-716.

Guilford, W.H. (1993) “Mechanical Interactions between Arterioles and the Interstitium” Dissertation, University of Arizona, Tucson.

Guilford, W.H. (2001) "Laser Traps in Cell Biology and Biophysics" in Methods in Cellular Imaging, ed. A. Periasami (Oxford University Press), pp. 381-94.

Other Publications

Guilford, W.H. (2003) “The Business of Teaching” C-VILLE 15(16): 5.

Guilford, W.H. (2003) “Motors as they were meant to be.” BioEssays, 25(10): 1021-22.

Conference Presentations

Crissman, R.S. and W.H. Guilford (1981) "A SEM Study of the Elastic Network in the Canine Hepatic Portal Vein." Anatomical Record 199: 60A - 61A.

Crissman, R.S., W.H. Guilfordand M.L. Fitzpatrick (1982) "The Network of Elastic Fibers in Venous Valves as Observed by Scanning Electron Microscopy." Anatomical Record 202: 37A - 38A.

Guilford, W.H. and R.S. Crissman (1983) "Mechanical Properties of the Networks of Elastic Fibers in the Canine Lateral Saphenous Vein." Ohio Journal of Science 83(2): 30.

Guilford, W.H. and R.W. Gore (1991) “A New, Remote-Sensing Micro-Force Transducer” Proceedings of the Fifth World Congress on Microcirculation (Louisville, KY) pg. 34.

Guilford, W.H. and R.W. Gore (1992) “A New Remote-Sensing Isometric Force Transducer” FASEB Journal 6(1): A172 (985).

Guilford, W.H. and R.W. Gore (1992) “The Micro-Mechanical Properties of the Interstitium Surrounding Arterioles in the Hamster Cheek Pouch” FASEB Journal 6(5): A2074 (M035).

Guilford, W.H, R.C. Lantz and R.W. Gore (1993) “The Forces Generated by Single Neutrophils and Macrophages Migrating in vivo and in vitro” FASEB Journal 7(3): A365 (2112).

Guilford, W.H., R.C. Lantz and R.W. Gore (1994) “The forces generated by single alveolar macrophages stimulated by chemoattractants.” FASEB Journal 8(4): A45 (258).

Guilford, W.H., R.C. Lantz and R.W. Gore (1994) “The forces generated by single leukocytes during spontaneous movement.” FASEB Journal 8(4): A1041 (M056).

Guilford, W.H. and R.W. Gore (1994) “Mechanical interactions between arterioles and the interstitium.” FASEB Journal 8(4): A1041 (M055).

Gore, R.W. and W.H. Guilford. (1994) “Quantitative measurements of forces generated by single leukocytes during spontaneous migration in vivo and in vitro.” 18th European Conference for Microcirculation. Rome, Italy. September 4-8, 1994.

Gore, R.W. and W.H. Guilford. (1994) “Quantitative measurements of forces generated by single alveolar macrophages stimulated by the chemoattractant (fMLP).” 18th European Conference for Microcirculation. Rome, Italy. September 4-8, 1994.

Guilford, W.H., J. Wu, G. Kennedy and D.W. Warshaw (1995) “Step size and unitary force measured in both smooth and skeletal muscle myosin” Biophysical Journal, 68 (2, part 2): A238.

Dupuis, D.E., W.H. Guilford and D.M. Warshaw (1996) “Flexural rigidity of actin filaments studied in the laser light trap” Biophysical Journal, 70 (2, part 2): A268.

Guilford, W.H., M.J. Tyska, Y. Freyzon, D.M. Warshaw and K.M. Trybus (1996) “Smooth muscle myosin with an elongated neck region produces greater unitary displacements in vitro” Biophysical Journal, 70 (2, part 2): A127.

Guilford, W.H., J.B. Patlak and D.M. Warshaw (1997) "Mean-variance analysis of forces and displacements generated by myosin in the laser trap." Biophysical Journal, 72(2): A181.

Guilford, W.H., A.M. Lauzon, Y. Freyzon, D.M. Warshaw and K.M. Trybus (1997) "Myosin without the putative lever arm still generates steps in the laser trap." Biophysical Journal, 72(2): A221.

Guilford, W.H., D.E. Dupuis, D.M. Warshaw, S. Guillermina, K.M. Trybus and S. Lowey (1998) “Double-headed smooth and skeletal muscle myosins generate displacements by cooperative action of the two heads.” Biophysical Journal, 74(2): A225.

Cheezum, M.K., W.F. Walker and W.H. Guilford (1999) "A comparison of algorithms for tracking fluorescent particles." Second Conference on the Development of Technology in Medicine in Virginia, November 1, 1999, P-9.

Cheezum, M.K, W.F. Walker and W.H. Guilford (2000) "A comparison of particle tracking algorithms: implications for in vitro motility and single molecule fluorescence." Biophysical Journal, 78(1): 249A.

Dascalu, D., J.A. Tournas and W.H. Guilford (2001) “Controlling time-shared laser traps using a digital signal processing board.” Biophysical Journal, 80(1):73a.

Dascalu, D., B.A. Ramos and W.H. Guilford (2001) "Simultaneous creation and monitoring of multiple laser traps by digital signal processing and back focal plane interferometry." 55^th Annual Meeting and Symposium of the Society of General Physiologists, Woods Hole, Massachusetts.

Guilford, W.H. (2001) “A problem-based approach to teaching cell and molecular biology to engineers.” Proceedings of the ASEE Annual Conference and Exposition, Albuquerque, New Mexico.

Guilford, W.H., K. Kirby-Smith, L.R. La Bonte, L.J. Rinko, B. Guo and B.A. French (2001) “Peroxynitrite affects the performance of actin and cardiac myosin in the in vitro motility assay” 5^th International Muscle Energetics Conference, Burlington, Vermont

Rinko, Linda K., William H. Guilford, Michael B. Lawrence and Klaus F. Ley. (2002) “The Load-dependant Bond Rupture Kinetics of L and P-selectin from PSGL-1 Measured in the Laser Trap” 3^rd Annual Colloquium on the Biomechanics of Adhesion Molecules, University of Virginia, Charlottesville.

Kirby-Smith, C., L.R. La Bonte and W.H. Guilford (2003) “Peroxynitrite reduces the calcium sensitivity of cardiac thin filaments” Annual Meeting of the Biophysical Society, San Antonio, TX.

La Bonte, L.R., Z. Yang, W.H. Guilford and B.A. French (2003) “Left Ventricular Dysfunction in Non-infarcted Regions of the Heart Early After Myocardial Infarction: A Disease of Myosin?”Annual Meeting of the Biophysical Society, San Antonio, TX.

Petrie, C.E. and W.H.Guilford (2003) “A Quantitative Comparison of Blocking Agents Used in the In Vitro Motility Assay” Annual Meeting of the Biophysical Society, San Antonio, TX.

Guo, B. and W.H. Guilford (2003) “Energy Landscapes of Actin-Myosin Bonds in Different Nucleotide Binding States” 4^th Annual Colloquium on Cellular and Molecular Biomechanics, Charlottesville, VA.

Watson, D.S., W.O. Hancock and W.H. Guilford (2004) “Peroxynitrite Impairs Kinesin-Driven Microtubule Motility In Vitro” Biophysical Journal, 86(1S): 409a.

Guo, B. and W.H.Guilford (2004) “Energy Landscapes of Actin-myosin Bonds in Different Nucleotide States” Biophysical Journal, 86(1S): 53a.

Guo, B. and W.H.Guilford (2004) “The Tail of Myosin Reduces Actin Filament Velocities in the In Vitro Motility Assay” Biophysical Journal, 86(1S): 53a.


	Dr. Bill's Publications
	Peer-Reviewed Journal Articles Crissman, R.S. and W.H. Guilford (1984) "The Three-Dimensional Architecture of the Elastic Fiber Network in Canine Hepatic Portal System." American Journal of Anatomy 171: 401-13. Grdina, D.J., W.H. Guilford, C.P. Sigdestad and C.S. Giometti (1988) “Effects of Radioprotectors on DNA Damage and Repair, Proteins, and Cell-cycle Progression.” Pharmacology and Therapeutics 39: 133-7. Sigdestad, C.P., W. Guilford, J. Perrin and D.J. Grdina (1988) “Cell Cycle Redistribution of Cultured Cells After Treatment With Chemical Radiation Protectors.” Cell and Tissue Kinetics 21(3): 193-200. Guilford, W.H. R.W. Gore (1992) “A Novel, Remote-Sensing, Isometric Force Transducer for Micro-Mechanics Studies” American Journal of Physiology 263 (Cell Physiology 32): C700-707. VanBuren, P., W.H. Guilford, G. Kennedy, J. Wu and D.M. Warshaw (1995) “Smooth Muscle Myosin: A High Force-Generating Molecular Motor” Biophysical Journal, 68: 256s-259s. Guilford, W.H, R.W. Gore and R.C. Lantz (1995) “The locomotive forces produced by single leukocytes in vivo and in vitro” American Journal of Physiology, 268 (Cell Physiology 37): C1308-12 . Guilford, W. H. and R.W. Gore (1995) “The Mechanics of Arteriolar-Tissue Interaction.” Microvascular Research, 50: 260-287. Dupuis, D.E., W.H. Guilford, J. Wu and D.M. Warshaw (1996) “Actin Filament Mechanics in the Laser Trap” Journal of Muscle Research and Cell Motility, 18 (1): 17-30. Guilford, W.H., D.E. Dupuis, G. Kennedy, J. Wu, J.B. Patlak and D.M. Warshaw (1997) “Smooth and Skeletal Muscle Myosins Produce Similar Unitary Forces and Displacements in the Laser Trap.” Biophysical Journal, 72 (3): 1006-21 Guilford, W.H. and D.M. Warshaw (1998) “The Molecular Mechanics of Smooth Muscle Myosin” Comparative Biochemistry and Physiology, Part B, 119: 451-58. Tyska, M.J., D.E. Dupuis, W.H. Guilford, J.B. Patlak, G.S. Waller, K.M. Trybus, D.M. Warshaw, and S. Lowey (1999) “Two Heads of Myosin are Better than One for Generating Force and Motion” Proceedings of the National Academy of Sciences, 96: 4402-7. Warshaw,D.M. W.H. Guilford, Y. Freyzon, E. Krementsova, K.A. Palmiter, M.J. Tyska, J.E. Baker, and K.M. Trybus (2000 “The Light Chain Binding Domain of Expressed Smooth Muscle Heavy Meromyosin Acts as a Mechanical Lever” Journal of Biological Chemistry, 275: 37167-37172. Guilford, W.H. (2001) "Teaching Peer-review and the Process of Scientific Writing" Advances in Physiology Education, 25: 167-175. Cheezum, M.K., W.F. Walker and W.H. Guilford (2001)"Quantitative comparison of algorithms for tracking single fluorescent particles." Biophysical Journal, 81: 2378-88. Rinko, L.J., M.B. Lawrance and W.H. Guilford (2004) “The Molecular Mechanics of P- and L-selectin Lectin Domains Binding to PSGL-1” Biophysical Journal, 86: 544-54. Guilford, W.H., J.A. Tournas, D. Dascalu, and D.S. Watson (2004) “Creating multiple, time-shared laser traps with simultaneous displacement detection using digital signal processing hardware.” Analytical Biochemistry, 326(2): 153-66. Guo, B. and W.H. Guilford (2004) "The Tail of Myosin Reduces Actin Filament Velocity in the in vitro Motility Assay" Cell Motility and the Cytoskeleton, 59: 264-72. Guilford, W.H. (2004) “Teaching Cell and Molecular Biology within the Context of Human Disease.” In press Thesis / Book Chapters Winfree, A.T. and W. Guilford (1988) "The Dynamics of Organizing Centers: Numerical Experiments in Differential Geometry." in Biomathematics and Related Computational Problems, ed. L.M. Ricciardi (Kluwer Academic Publishers), pp. 697-716. Guilford, W.H. (1993) “Mechanical Interactions between Arterioles and the Interstitium” Dissertation, University of Arizona, Tucson. Guilford, W.H. (2001) "Laser Traps in Cell Biology and Biophysics" in Methods in Cellular Imaging, ed. A. Periasami (Oxford University Press), pp. 381-94. Other Publications Guilford, W.H. (2003) “The Business of Teaching” C-VILLE 15(16): 5. Guilford, W.H. (2003) “Motors as they were meant to be.” BioEssays, 25(10): 1021-22. Conference Presentations Crissman, R.S. and W.H. Guilford (1981) "A SEM Study of the Elastic Network in the Canine Hepatic Portal Vein." Anatomical Record 199: 60A - 61A. Crissman, R.S., W.H. Guilfordand M.L. Fitzpatrick (1982) "The Network of Elastic Fibers in Venous Valves as Observed by Scanning Electron Microscopy." Anatomical Record 202: 37A - 38A. Guilford, W.H. and R.S. Crissman (1983) "Mechanical Properties of the Networks of Elastic Fibers in the Canine Lateral Saphenous Vein." Ohio Journal of Science 83(2): 30. Guilford, W.H. and R.W. Gore (1991) “A New, Remote-Sensing Micro-Force Transducer” Proceedings of the Fifth World Congress on Microcirculation (Louisville, KY) pg. 34. Guilford, W.H. and R.W. Gore (1992) “A New Remote-Sensing Isometric Force Transducer” FASEB Journal 6(1): A172 (985). Guilford, W.H. and R.W. Gore (1992) “The Micro-Mechanical Properties of the Interstitium Surrounding Arterioles in the Hamster Cheek Pouch” FASEB Journal 6(5): A2074 (M035). Guilford, W.H, R.C. Lantz and R.W. Gore (1993) “The Forces Generated by Single Neutrophils and Macrophages Migrating in vivo and in vitro” FASEB Journal 7(3): A365 (2112). Guilford, W.H., R.C. Lantz and R.W. Gore (1994) “The forces generated by single alveolar macrophages stimulated by chemoattractants.” FASEB Journal 8(4): A45 (258). Guilford, W.H., R.C. Lantz and R.W. Gore (1994) “The forces generated by single leukocytes during spontaneous movement.” FASEB Journal 8(4): A1041 (M056). Guilford, W.H. and R.W. Gore (1994) “Mechanical interactions between arterioles and the interstitium.” FASEB Journal 8(4): A1041 (M055). Gore, R.W. and W.H. Guilford. (1994) “Quantitative measurements of forces generated by single leukocytes during spontaneous migration in vivo and in vitro.” 18th European Conference for Microcirculation. Rome, Italy. September 4-8, 1994. Gore, R.W. and W.H. Guilford. (1994) “Quantitative measurements of forces generated by single alveolar macrophages stimulated by the chemoattractant (fMLP).” 18th European Conference for Microcirculation. Rome, Italy. September 4-8, 1994. Guilford, W.H., J. Wu, G. Kennedy and D.W. Warshaw (1995) “Step size and unitary force measured in both smooth and skeletal muscle myosin” Biophysical Journal, 68 (2, part 2): A238. Dupuis, D.E., W.H. Guilford and D.M. Warshaw (1996) “Flexural rigidity of actin filaments studied in the laser light trap” Biophysical Journal, 70 (2, part 2): A268. Guilford, W.H., M.J. Tyska, Y. Freyzon, D.M. Warshaw and K.M. Trybus (1996) “Smooth muscle myosin with an elongated neck region produces greater unitary displacements in vitro” Biophysical Journal, 70 (2, part 2): A127. Guilford, W.H., J.B. Patlak and D.M. Warshaw (1997) "Mean-variance analysis of forces and displacements generated by myosin in the laser trap." Biophysical Journal, 72(2): A181. Guilford, W.H., A.M. Lauzon, Y. Freyzon, D.M. Warshaw and K.M. Trybus (1997) "Myosin without the putative lever arm still generates steps in the laser trap." Biophysical Journal, 72(2): A221. Guilford, W.H., D.E. Dupuis, D.M. Warshaw, S. Guillermina, K.M. Trybus and S. Lowey (1998) “Double-headed smooth and skeletal muscle myosins generate displacements by cooperative action of the two heads.” Biophysical Journal, 74(2): A225. Cheezum, M.K., W.F. Walker and W.H. Guilford (1999) "A comparison of algorithms for tracking fluorescent particles." Second Conference on the Development of Technology in Medicine in Virginia, November 1, 1999, P-9. Cheezum, M.K, W.F. Walker and W.H. Guilford (2000) "A comparison of particle tracking algorithms: implications for in vitro motility and single molecule fluorescence." Biophysical Journal, 78(1): 249A. Dascalu, D., J.A. Tournas and W.H. Guilford (2001) “Controlling time-shared laser traps using a digital signal processing board.” Biophysical Journal, 80(1):73a. Dascalu, D., B.A. Ramos and W.H. Guilford (2001) "Simultaneous creation and monitoring of multiple laser traps by digital signal processing and back focal plane interferometry." 55^th Annual Meeting and Symposium of the Society of General Physiologists, Woods Hole, Massachusetts. Guilford, W.H. (2001) “A problem-based approach to teaching cell and molecular biology to engineers.” Proceedings of the ASEE Annual Conference and Exposition, Albuquerque, New Mexico. Guilford, W.H., K. Kirby-Smith, L.R. La Bonte, L.J. Rinko, B. Guo and B.A. French (2001) “Peroxynitrite affects the performance of actin and cardiac myosin in the in vitro motility assay” 5^th International Muscle Energetics Conference, Burlington, Vermont Rinko, Linda K., William H. Guilford, Michael B. Lawrence and Klaus F. Ley. (2002) “The Load-dependant Bond Rupture Kinetics of L and P-selectin from PSGL-1 Measured in the Laser Trap” 3^rd Annual Colloquium on the Biomechanics of Adhesion Molecules, University of Virginia, Charlottesville. Kirby-Smith, C., L.R. La Bonte and W.H. Guilford (2003) “Peroxynitrite reduces the calcium sensitivity of cardiac thin filaments” Annual Meeting of the Biophysical Society, San Antonio, TX. La Bonte, L.R., Z. Yang, W.H. Guilford and B.A. French (2003) “Left Ventricular Dysfunction in Non-infarcted Regions of the Heart Early After Myocardial Infarction: A Disease of Myosin?”Annual Meeting of the Biophysical Society, San Antonio, TX. Petrie, C.E. and W.H.Guilford (2003) “A Quantitative Comparison of Blocking Agents Used in the In Vitro Motility Assay” Annual Meeting of the Biophysical Society, San Antonio, TX. Guo, B. and W.H. Guilford (2003) “Energy Landscapes of Actin-Myosin Bonds in Different Nucleotide Binding States” 4^th Annual Colloquium on Cellular and Molecular Biomechanics, Charlottesville, VA. Watson, D.S., W.O. Hancock and W.H. Guilford (2004) “Peroxynitrite Impairs Kinesin-Driven Microtubule Motility In Vitro” Biophysical Journal, 86(1S): 409a. Guo, B. and W.H.Guilford (2004) “Energy Landscapes of Actin-myosin Bonds in Different Nucleotide States” Biophysical Journal, 86(1S): 53a. Guo, B. and W.H.Guilford (2004) “The Tail of Myosin Reduces Actin Filament Velocities in the In Vitro Motility Assay” Biophysical Journal, 86(1S): 53a. · Home · People · Research · · Equipment · Facilities · Goodies ·