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Ultrasound and Microbubbles |
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| Microbubbles, with a size approximately
matching that of a red blood cell (or smaller) are being investigated for
therapeutic applications - including drug delivery and gene delivery. Using
microbubbles is attractive in that the drug can be delivered with precision.
Thus, drugs that are frequently relatively toxic to both healthy tissue
and diseased tissue can be used with fewer undesirable side-effects.
Research groups in the University of Virginia, and elsewhere, are developing biologically active surface chemistries that cause the bubbles to stick to regions of disease. This approach is termed 'targeting'. The University of Virginia has particularly strong research groups active in these areas (in the Cardiovascular Division (Kaul, Lindner, Klibanov etc.) and within Biomedical Engineering (Price, Song etc.) We collaborate with these groups and support the development of ultrasound transducers and associated hardware required for both activating the bubbles (breaking them) and visualizing them. |
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