JEFFREY F. ELLENA

507 Woodmont Dr. Charlottesville, VA 22901

Work: 804-924-3163 Home: 804-977-3726 email: jfe@virginia.edu

Professional Experience:

January, 1984 to Present

Chemistry Department University of Virginia

Senior Scientist, NMR spectroscopist

Professional Association:

The Biophysical Society

Education:

University of Virginia, Chemistry Dept.	Postdoctoral Associate, 1983	U.S. National Eye Institute Postdoctoral Fellow
University of California, Davis, Biochemistry Dept.	Graduate Student, 1977-82, Ph.D. in Biochemistry	USPHS Predoctoral Training Grant, 1977-81, UC, Davis Jastro-Shields Research Scholarship, 1981-82
University of Massachusetts, Amherst	Undergraduate Student, 1972-76, B.S. in Biochemistry	Phi Kappa Phi, 1973 Phi Beta Kappa, 1975

Publications:

Ellena, J.F., and McNamee, M.G., Interaction of Spin-Labeled Naja Naja Siamensis alpha-Neurotoxin with Acetylcholine Receptor from Torpedo Californica, FEBS Lett. 110, 301-304, (1980).

McNamee, M.G., Ellena, J.F., and Dalziel, A.W., Lipid-Protein Interactions in Membranes Containing the Acetylcholine Receptor, Biophysical J. 37, 103-104, (1982).

Ellena, J.F., Blazing, M.F., and McNamee, M.G., Lipid-Protein Interactions in Reconstituted Membranes Containing the Acetylcholine Receptor, Biochemistry 22, 5523-5535, (1983).

Sefcik, M.D., Schaefer, J., Stejskal, E.O., McKay, R.A., Ellena, J.F., Dodd, S.W., and Brown, M.F., Lipid Bilayer Dynamics and Rhodopsin-Lipid Interactions: New Approach Using High Resolution Solid-State Carbon-13 NMR, Biochem. Biophys. Res. Commun. 114, 1048-1055, (1983).

Ellena, J.F., Hutton, W.C., and Cafiso, D.S., Elucidation of Cross-Relaxation Pathways in Phospholipid Vesicles Utilizing Two-Dimensional H-1 NMR Spectroscopy, J. Amer. Chem. Soc. 107, 1530-1537, (1985).

Brown, M.F., Ellena, J.F., Trindle, C., and Williams, G.D., Frequency Dependence of Spin-Lattice Relaxation Times of Lipid Bilayers, J. Chem. Phys. 84, 465-470, (1986).

Ellena, J.F., Pates, R.D., and Brown, M.F., P-31 NMR Spectra of Rod Outer Segement and Sarcoplasmic Reticulum Membranes Show No Evidence of Immobilized Components Due to Lipid-Protein Interactions, Biochemistry 25, 3742-3748, (1986).

Ellena, J.F., Ni, W.-T., and Ueng, T.-S., Precision NMR Measurement of Li-7 and Limits on Spatial Anisotropy, CPEM 86 Digest. Institute of Electrical and Electronic Engineers, 13-14, (1986).

Ellena, J.F., Dominey, R.N., and Cafiso, D.S., Molecular Dynamics in Sodium Dodecyl Sulfate Micelles Elucidated Using C-13 and H-1 Spin-Lattice Relaxation, C-13 Spin-Spin Relaxation, and H-1 Nuclear Overhauser Effect Spectroscopy, J. Phys. Chem. 91, 131-137, (1987).

Kauzlarich, S.M., Ellena, J.F., Stupik, P.D., Reiff, W.M., and Averill, B.A., Spectroscopic and Magnetic Properties of FeOCl Intercalated with Organosulfur Electron Donors, J. Amer. Chem. Soc. 109, 4561-4570, (1987).

Ellena, J.F., Dominey, R.N., Archer, S.J., Xu, Z.-C., and Cafiso, D.S., Localization of Hydrophobic Ions in Phospholipid Bilayers Using H-1 Nuclear Overhauser Effect Spectroscopy, Biochemistry 26, 4584-4592, (1987).

Ellena, J.F., Archer, S.J., Dominey, R.N., Hill, B.D., and Cafiso, D.S., Localizing the Nitroxide Group of Fatty Acid and Voltage-Sensitive Spin Labels in Phospholipid Bilayers, Biochim. Biophys. Acta 940, 63-70, (1988).

Archer, S.J., Ellena, J.F., and Cafiso, D.S., Dynamics and Aggregation of the Peptide Ion Channel Alamethicin, Biophysical J. 60, 389-398, (1991).

Lepore, L.S., Ellena, J.F., and Cafiso, D.S., A Comparison of the Lipid Acyl Chain Dynamics between Small and Large Unilamellar Vesicles, Biophysical J. 61, 767-775, (1992).

Kelsh, L.P., Ellena, J.F., and Cafiso, D.S., Determination of the Molecular Dynamics of Alamethicin Using C-13 NMR: Implications for the Mechanism of Gating of a Voltage-Dependent Channel, Biochemistry 31, 5136-5144, (1992).

Ellena, J.F., Lepore, L.S., and Cafiso, D.S., Estimating Lipid Lateral Diffusion in Phospholipid Vesicles from C-13 Spin-Spin Relaxation, J. Phys. Chem. 97, 2952-2957, (1993).

Franklin, J.C., Ellena, J.F., Jayasinghe, S., Kelsh, L.P., and Cafiso, D.S., The Structure of Micelle Associated Alamethicin from H-1 NMR. Evidence for Conformational Heterogeneity in a Voltage-Gated Peptide, Biochemistry 33, 4036-4045, (1994).

Manderville, R.A., Ellena, J.F., and Hecht, S.M., Solution Structure of a Zn(II) Bleomycin A₅-d(CGCTAGCG)₂ Complex, J. Amer. Chem. Soc. 116, 10851-10852, (1994).

Baber, J., Ellena, J.F., and Cafiso, D.S., Distribution of General Anesthetics in Phaspholipid Bilayers Determined using ²H NMR and ¹H-¹H NOE Spectroscopy, Biochemistry 34, 6533-6539, (1995).

Manderville, R.A., Ellena, J.F., and Hecht, S.M., Interaction of Zn(II)Bleomycin with d(CGCTAGCG)₂. A Binding Model Based on NMR Experiments and Restrained Molecular Dynamics Calculations, J. Amer. Chem. Soc. 117, 7891-7903, (1995).

Zajicek, J., Ellena, J.F., Williams, G.D., Khadim, M.A., and Brown, M.F., Molecular Dynamics of Vesicles of Unsaturated Phosphatidylcholines Studied by ¹³C NMR Spin-Lattice Relaxation, Collect. Czech. Chem. Commun. 60, 719-735, (1995).

McGarvey, G.J., Stepanian, M., Bressette, A.R., and Ellena, J.F., Cis- and Trans-1,7,9-Trioxadispiro[5.1.5.3]Hexadecane - Stability Studies and Solution Structures, Tetrahedron Letters, 37, 5465-5468, (1996).

Briercheck, D.B., Allison, T.J., Richardson, J.P., Ellena, J.F., Wood, T.C., Rule, G.S., ¹H, ¹⁵N, and ¹³C Resonance Assignments and Secondary Structure Determination of the RNA-Binding Domain of E. Coli Rho Protein, J. Biomol. NMR 8, 429-444, (1996).

Jayasinghe, S., Barranger-Mathys, M., Ellena, J.F., Franklin, C., and Cafiso, D.S., Structural Features That Modulate the Transmembrane Migration of a Hydrophobic Peptide in Lipid Vesicles, Biophys. J. 74, 3023-3030, (1998).

Sucheck, S.J., Ellena, J.F., and Hecht, S.M., Characterization of Zn(II) Deglycobleomycin A2 and Interaction with d(CGCTAGCG)₂. Direct Evidence for Minor Binding of the Bithiazole Moiety, J. Amer. Chem. Soc., 120, 7450-7460, (1998).

Ellena, J.F., Le, M., Cafiso, D.S., Solis, R.M., Langston, M., and Sankaram, M.B., Distribution of Phospholipids and Triglycerides in Multivesicular Particles, Drug Delivery, 6, 97-106, (1999).