Ray Keller's Lab
University of Virginia - Dept. of
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14 hours of development, from
gastrulation thru neural tube closure (viewed from the
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of convergent extension in the neural plate, and
the mechanisms of neural
What cell behaviors shape the neural plate and how
are they regulated by midline-originating
We are measuring the forces
generated by tissue movements, and the biomechanical properties of
those tissues to understand the mechanical basis of morphogenesis.
interested in the biomechanical role of such
molecules as integrin,
during convergence and extension of the mesoderm.
How do molecular components such as these and
others such as members of the planar cell polarity
pathway drive or guide convergence and extension
and axis elongation?
We are interested in
understanding the variation among species in the
mechanisms and biomechanics
of gastrulation. This include the mechanisms by
removed during gastrulation and neurulation, and
the degree to which different species use
vs. convergent thickening to drive blastopore closure.