Robert M. Berne
Cardiovascular Research Center
Leitinger Lab
Wamhoff Lab
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Dr. Brian R. Wamhoff
Assistant Professor of Medicine
Division of Cardiovascular Medicine
PhD, University of Missouri, 2001
wamhoff@virginia.edu
Dr. Wamhoff is an Assistant Professor in the Division of Cardiovascular Medicine in the Department of Medicine and a faculty member of the Robert M. Berne Cardiovascular Research Center at the University of Virginia. Dr. Wamhoff has a secondary appointment in Biomedical Engineering. A graduate of Rhodes College in 1996, Dr. Wamhoff received his PhD in medical physiology at the University of Missouri in Columbia, where he studied the effects of exercise, diabetes and atherosclerosis coronary function. In 2006, he completed a post-doctoral fellowship at the University of Virginia, which focused on the molecular mechanisms underlying the development of atherosclerosis. While at the University of Virginia, Dr. Wamhoff played a critical role in developing a novel drug eluting stent to combat instent restenosis. Dr. Wamhoff’s lab began in 2006 and continues to focus on mechanisms of artery stenosis from both an acute injury perspective and chronic pathogenesis of atherosclerosis. The major cell type that the Wamhoff lab focuses on is the vascular smooth muscle cell. They employ the use of several highly innovative techniques, including laser capture microdissection, mouse Cre/lox technology for in vivo gene mutagenesis, novel in vivo vascular injury and atherosclerosis models and in conjunction with the Blackman lab, biomedical models/devices that mimic the artery in vitro. This integrated approach to understanding the vascular smooth has allowed them to fully understand the disease process from the DNA level in vitro to the whole animal level in vivo with a strong emphasis of translating findings to real human translational events.
