We also seek to develop a novel 3-D biodegradable polyphosphazene based scaffold in a dynamic flow environment in NASA rotating bioreactors suitable for bone tissue engineering. We will design, fabricate, characterize, and optimize 3-D polyphosphazene scaffolds for bone tissue engineering under a dynamic flow environment in NASA rotating bioreactors.
interdisciplinary projects address fundamental issues facing bone
remodeling and formation, particularly regarding the effects of an in
vitro dynamic flow environment in bioreactors on bone cell biology
and bone formation in
vivo. Results from these studies will serve as the
foundation for future work aimed at exploring the effect of dynamic flow
environment on bone healing and remodeling, and for optimizing
bioreactor tissue engineering of bone.