Using the biodegradable polymer poly (lactide-co-glycolide), we have developed a series of 3-dimensional porous structures based on microsphere technology. In combination with bone morphogenetic proteins and osteoblasts, these matrices will serve as scaffolds for bone regeneration.
research also focuses on the development and evaluation of
polyphosphazene-ceramic composites that could be used as scaffolds for
bone tissue engineering.
studies examining cell growth on these matrices, we have utilized an
osteoblast cell lines as well as bone cells isolated from rat calvaria
to create a model system for cell growth on bioerodable materials. This
image shows osteoblasts growing on the surface of our 3-D microsphere
matrix. It is interesting to note that the cells are growing in a
circumferential pattern due to the structure of the matrix.