anterior cruciate ligament (ACL) is the most commonly injured ligament
of the knee, due to inherently poor healing potential and limited
vascularization ACL ruptures do not heal and surgical replacement is
often required. Our laboratory has produced a cell-seeded, degradable,
three-dimensional (3-D) scaffold for ACL replacement and regeneration.
Three-dimensional braiding techniques have been used to create a
scaffold with optimized pore size for cell proliferation and tissue
ingrowth, resistance to wear and rupture, and mechanical properties
comparable to natural ACL.
Presently, we are optimizing this structure to improve the
biomechanical properties, adjust degradation time, and enhance the cell
proliferation and tissue regeneration
abilities of the implant.
These changes will result in an implant that berhaves more like
natural ligament and enhances regeneration without rupturing after