Cell signaling is the biochemical process cells use to make decisions about virtually everything they do – migrate, differentiate, survive, die, and more. Signaling involves networks of intracellular proteins whose concentrations, modification states, or localization change in response to events such as receptor-ligand binding. Cells interpret these signaling network changes, using rules scientists are only beginning to decipher, to execute decision processes. While proper signaling is critical to normal development and health, aberrant signaling leads to numerous diseases, including cancer. Thus, the ability to engineer signaling processes or intervene effectively in aberrant signaling has huge medical implications. Our lab integrates experimental and computational methods to study fundamental aspects of cell signaling regulation and applied aspects of cell signaling including the efficacy of therapeutics that target particular signaling pathways in cancer.

Open Positions

The Lazzara Lab seeks enthusiastic applicants to fill open positions for postdoctoral research associates, graduate research assistants, laboratory technical staff, and undergraduate researchers with a start date of October 1, 2016 or later. Candidates should send a current c.v. to mlazzara@virginia.edu.


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The Lazzara Lab is very excited to be moving to the University of Virginia in August 2016! Positions are open!

Lazzara Lab awarded new NIH R21 funding to collaborate with lab of Dr. Damien Thevenin (Lehigh University) to study signaling regulation by PTPRJ/DEP1 (Dec 2015).

Lazzara Lab awarded NSF CBET grant to study signaling regulation by SHP2 in glioblastoma (Aug 2015).

Matt Lazzara is the recipient of a 2015 Research Scholar Grant from the American Cancer Society (July 2015).

Janine Buonato's paper on the role of SHP2 in EMT published in the Journal of Cell Science.

Chris Furcht's paper published in Science Signaling. "EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR."

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