Cell signaling is the biochemical process cells use to make decisions about virtually everything they do – migrate, differentiate, survive, die, and more. Signaling involves networks of intracellular proteins whose concentrations, modification states, or localization change in response to events such as receptor-ligand binding. Cells interpret these signaling network changes, using rules scientists are only beginning to decipher, to execute decision processes. While proper signaling is critical to normal development and health, aberrant signaling leads to numerous diseases, including cancer. Thus, the ability to engineer signaling processes or intervene effectively in aberrant signaling has huge medical implications. Our lab integrates experimental and computational methods to study fundamental aspects of cell signaling regulation and applied aspects of cell signaling including the efficacy of therapeutics that target particular signaling pathways in cancer.

Open Positions

The Lazzara Lab seeks enthusiastic applicants to fill open positions for postdoctoral research associates, graduate research assistants, laboratory technical staff, and undergraduate researchers. Candidates should send a current c.v. to mlazzara@virginia.edu.


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Matt Lazzara is the lead PI on a new collaborative research grant funded by the NSF MCB Division. The project will leverage gene editing, live-cell imaging, and computational modeling to develop unprecedented understanding of the coupling between receptor trafficking and signaling. Collaborating PIs include: Alexander Sorkin (Pitt), Leslie Lowe (UConn), and Kevin Brown (UConn). [Aug 2017]

Matt Lazzara co-authors Integrative Biology paper entitled "An engineering design approach to systems biology" with colleagues at UVA, MIT, and Howard. [May 2017]

The Lazzara Lab traveled to Phoenix, AZ to give two presentations at the annual meeting of the Society for Neurooncology. [November 2016]

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