Publications

  1. Janes KA, Chandran PL, Ford RM, Lazzara MJ, Papin JA, Peirce SM, Saucerman JJ, and Lauffenburger DA. An engineering design approach to systems biology. Integr Biol 9: 574-583, 2017.
  2. Day EK, Sosale NG, and Lazzara MJ. Cell Signaling Regulation by Protein Phosphorylation: A Multivariate, Heterogeneous, and Context-dependent Process. Current Opinion in Biotechnology 40: 185–192, 2016.
  3. Buonato JM, Lan IS, and Lazzara MJ. EGF augments TGFβ-induced epithelial-mesenchymal transition by promoting SHP2 binding to GAB1. Journal of Cell Science 128: 3898-3909, 2015.
  4. Furcht CM, Buonato JM, and Lazzara MJ. EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR. Science Signaling 8: ra46, 2015. [Featured by Faculty of 1000.]
  5. Walsh AM, Kapoor GS, Buonato JM, Mathew LK, Bi Y, Davuluri RV, Simon MC, O’Rourke DM, and Lazzara MJ. Sprouty2 drives drug resistance and proliferation in glioblastoma. Molecular Cancer Research 13: 1227-37, 2015. [Selected by American Association of Cancer Research (AACR) editors for the AACR Journal Conference Collection on Anticancer Drug Action and Drug Resistance.]
  6. Monast CS and Lazzara MJ. Identifying determinants of EGFR-targeted therapeutic biochemical efficacy using computational modeling. CPT Pharmacometrics Syst Pharmacol (Nature Publishing Group) 3: e141, 2014.
  7. Furcht CM, Buonato JM, Skuli N. Mathew LK, Munoz Rojas A, Simon MC, and Lazzara MJ. Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells. J Cell Sci 127: 3555-67, 2014.
  8. Senturk S, Yao Z, Camiolo M, Stiles B, Rathod T, Walsh AM, Nemajerova A, Lazzara MJ, Alttorki NK, Krainer A, Moll UM, Lowe SW, Cartegni L, and Sordella R. P53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proc Natl Acad USA 111: E3287-96, 2014.
  9. Walsh AM and Lazzara MJ. Differential parsing of EGFR endocytic flux among parallel internalization pathways in lung cancer cells with EGFR-activating mutations. Integr Biol 6: 312-323, 2014.
  10. Buonato JM and Lazzara MJ. ERK1/2 blockade prevents epithelial-mesenchymal transition and promotes cellular sensitivity to EGFR inhibition in lung cancer cells. Cancer Res 74: 309-319, 2014. [Published online ahead of print Oct 2013].
  11. Fogelgren B, Zuo Z, Buonato J, Vasilyev A, Baek J-I, Choi SY, Chacon-Heszele MF, Palmyre A, Polgar N, Dummond IA, Park KM, Lazzara MJ, and Lipschutz J. Exocyst Sec10 protects renal tubule cells from injury by EGFR/MAPK activation and effects on endocytosis. Am J Physiol Renal Physiol 307: F1334-41, 2014.
  12. Monast CS and Lazzara MJ. Diversity in dimerization topologies enables differential control of receptor tyrosine kinase phosphorylation dynamics. Cell Mol Bioeng 7: 86-98, 2014.  [Published online ahead of print Oct 2013.]
  13. Walsh AM and Lazzara MJ. Regulation of EGFR trafficking and cell signaling by Sprouty2 and MIG6 in lung cancer cells. J Cell Sci 126: 4339-4348, 2013.
  14. Lazzara MJ. Quantitative modeling approaches for understanding the roles of protein phosphatases in cell signaling regulation: Applications to metabolism. In Protein Tyrosine Phosphatase Control of Metabolism (Kendra Bence, ed.), Springer, 2013.
  15. Ercan D, Xu C, Yanagita M, Monast CS, Pratila CA, Boronat JM, Shimamura T, Rogers A, Repellin C, Capelletti M, Goetz E, Letai A, Garraway LA, Lazzara MJ, Rosen N, Gray NS, Wing K-K, and Jänne PA. Aberrant ERK signaling causes resistance to EGFR kinase inhibitors. Cancer Discov 2: 934-947, 2012.
  16. Furcht CM, Muñoz Rojas AR, Nihalani D, and Lazzara MJ. Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations. Oncogene 32: 2346-2355, 2013. [Published online ahead of print Jul 2012].
  17. Monast CS, Furcht CM, and Lazzara MJ. Computational model of the regulation of EGFR by protein tyrosine phosphatases. Biophys J 102: 2012-2021, 2012.
  18. Arif E, Wagner MC, Johnstone D, Wong H, George B, Pruthi P, Lazzara MJ, and Nihalani D. Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to podocyte membrane. Mol Cell Biol 10:2134-50, 2011.
  19. Lazzara MJ, Lane K, Chan R, Jasper P, Yaffe M, Sorger PK, Jacks T, Neel BG, and Lauffenburger DA. Incomplete SHP2-mediated ERK activation contributes to gefitinib sensitivity of lung cancer cells with EGFR-activation mutations. Cancer Res 70: 3843-385, 2010.
  20. Lazzara MJ and Lauffenburger DA. Quantitative modeling perspectives on the ErbB system of cell regulatory processes. Exp Cell Res 315: 717-725, 2009.
  21. Lazzara MJ and Deen WM. Model of albumin reabsorption in the proximal tubule. Am J Physiol Renal Physiol 292: F430-439, 2007.
  22. Hendriks BH, Griffiths GJ, Benson R, Kenyon D, Lazzara M, Swinton J, Beck S, Hickinson M, Beusmans JM, Lauffenburger DA, DeGraaf D. Decreased internalization of ErbB1 mutants in lung cancer is linked with a mechanism conferring sensitivity to gefitinib. IET Syst Biol 153: 457-466, 2006.
  23. Bolton GR, Boesch AW, and Lazzara MJ. The effects of flow rate on membrane capacity: Development and application of adsorptive membrane fouling models. J Memb Sci 279: 625-634, 2006.
  24. Bolton GR, LaCasse D, Lazzara MJ, and Kuriyel R. The fiber-coating model of biopharmaceutical depth filtration. AIChE J 51: 2978-2987, 2005.
  25. Deen WM and Lazzara MJ. Glomerular filtration of albumin: How small is the sieving coefficient? Kidney Int 66: S63-S64, 2004.
  26. van Roosmalen D, Lazzara MJ, van den Broeke LJP, Keurentjes JTF, and Blankschtein D. Protein partitioning driven by excluded-volume interactions in an aqueous nonionic micellar-gel system. Biotech Bioeng 87: 695-703, 2004.
  27. Lazzara MJ and Deen WM. Effects of concentration on the partitioning of macromolecule mixtures in agarose gels. J Colloid Interface Sci 272: 288-297, 2004.
  28. Deen WM, Lazzara MJ, and Myers BD. Structural determinants of glomerular permeability. Am J Physiol Renal Physiol 281: F579-F596, 2001.
  29. Lazzara MJ and Deen WM. Effects of plasma proteins on the sieving of tracer macromolecules in glomerular basement membrane. Am J Physiol Renal Physiol 281: F860-F868, 2001.
  30. Lazzara MJ, Blankschtein D, and Deen WM. Effects of multi-solute steric interactions on membrane partition coefficients. J Colloid Interface Sci 226: 112-122, 2000.