Epithelial-mesenchymal transition.

The cellular developmental process of epithelial-mesenchymal transition (EMT) is hijacked in a number of epithelial-derived cancers to produce cells that with increased potential to metastasize and resist therapy. Our lab has identified a key role for the ERK signaling pathway in this process and shown that this new understanding can potentially be leveraged to develop new strategies for rationally scheduling different types of therapy to promote overall improved response to therapy. We are now extending this analysis to study the basis of cooperative signaling through different classes of receptors that produces the most efficient EMT.

tumor spheroid