"Diagram to illustrate the potential synergy between informatics and 'wet' molecular biology in the analysis of the obese gene. Positional cloning of the obese gene product (leptin), led to the discovery o fa novel cytokine receptor, which had been correctly predicted on the basis of analysis in silicio."
from Rastan, S., and L.J. Beeley, "Functional genomics: going forwards from the databases," Current Opinion in Genetics and Develoment 1997, 7:777-783.