Extended Model-based Designs for Complex Phase I Clinical Trials

Publications:

• O'Quigley J, Conaway M. Extended model-based designs for more complex dose-finding studies. Statistics in Medicine (2011); 30: 2062–2069.

• O'Quigley J, Conaway M. Continual reassessment and related dose-finding designs. Statistical Science (2010); 25: 202–216.

• Iasonos A, O'Quigley J. Interplay of priors and skeletons in two-stage continual reassessment method. Statistics in Medicine (2012), 31: 4321 - 4336.

Drug Combinations:

• Wages N, Conaway M, O'Quigley J. Using the time-to-event continual reassessment method in the presence of partial orders. Statistics in Medicine (2013), 32: 131–141.
  

• Wages N, Conaway M, O’Quigley J. Continual reassessment method for partial ordering. Biometrics (2011); 67: 1555–1563.

• Wages N, Conaway M, O’Quigley J. Dose-finding design for multi-drug combinations. Clinical Trials (2011); 8: 380–389.

• Wages N, Conaway M. Specifications of a continual reassessment method design for phase I trials of combined drugs. Pharmaceutical Statistics (2013); accepted.
  

• Wages N, Varhegyi N. pocrm: An R package for Phase I trials of combinations of agents. (2013); working paper in review.

• Iasonos A, Zohar S, O'Quigley J. Incorporating lower grade toxicity information into dose finding designs. Clinical Trials (2011); 8: 370–379.

• An R package pocrm containing functions for the implementation and simulation of the continual reassessment method for partial ordering (POCRM) for use in phase I clinical trials of combinations of agents can be downloaded from the Comprehensive R Archive Network (CRAN). For Windows, the pocrm library can be downloaded from within R GUI by clicking on Packages/Install package(s), choose a mirror site, and locating pocrm. Questions regarding the R code, the literature, and the application of POCRM are welcome and should be sent here. 
  

• Phase I Trials for Multiple Treatment Schedules - Simulation

• Nonparametric Optimal Benchmark
  

• Wages, N. Dose-finding for Multi-drug Combinations. Continual Reassessment Method and Related Issues in Dose-finding Workshop. Paris, France. September 2011.

• Conaway M. Ordered Restricted Inference and Model-based Designs for Partial Orders. Continual Reassessment Method and Related Issues in Dose-finding Workshop. Paris, France. September 2011. 

• Conaway, M. Designs for Phase I Trials of Combinations of Agents. ENAR. Washington D.C. April 2012.

• Wages, N. The Problem of Partial Ordering in Phase I Clinical Trials. SRCOS Summer Research Conference. Jekyll Island, GA. June 2012.

• Iasonos, A. Intermediary Grade Toxicities in Phase I Clinical Trials: How Much Information Is There?. University of Virginia Division of Translational Research & Applied Statistics Seminar Series. Charlottesville, VA. September 2012. 

• O'Quigley J. Dose-finding Methodology. November 2012.