Michal Sabat

Director

Molecular Structure Laboratory

 

Ph.D., University of Wroclaw, Poland,1976

M.Sc., University of Wroclaw, Poland, 1970

Postdoctoral Associate,Department of Biochemistry, University of Wisconsin, Madison, WI, 1981-1983

Postdoctoral Fellow, Department of Chemistry, Northwestern University, Evanston, IL, 1980-1981


Address:

Department of Chemistry
University of Virginia
McCormick Road
Charlottesville, VA 22904
Phone: (434)-924-7862
Fax: (434)-924-3710
E-mail: ms5c@virginia.edu


 

Research Interests

 

 Biophysical Chemistry of Nucleic Acids

 Bioinorganic Chemistry. Synthesis, Structure and Properties of NucleicAcid-Metal Ion Complexes

 Molecular Modeling and Computational Chemistry of Biological Systems.

 


Awards

1999 David Harrison III Award for Undergraduate Advising.


Representative Publications

Recent Reviews

“Structural Aspects of Pt-Purine Interactions: From Models to DNA”, R.Bau and M.Sabat in: Cisplatin:Chemistry and Biochemistry of a Leading Anticancer Drug, B.Lippert, Ed. Wiley-VCH, 1999, p.319-337.

 “Ternary Metal Ion-Nucleic Acid Base-Protein Complexes", M. Sabat in: Metal Ions in Biological Systems Vol. 32, A. Sigel and H. Sigel, Eds., Marcel Dekker, Inc., New York, 1996, p. 521-556.

“Metal Ions in Multiple-Stranded DNA", M. Sabat and B. Lippert in: Metal Ions in Biological Systems Vol. 33, A. Sigel and H. Sigel, Eds., Marcel Dekker, Inc., New York, 1996, p.143-176.

Bioinorganic Chemistry of Nucleic Acids

“Metal-Stabilized Rare Tautomers of Nucleobases. 8. Promotion of Rare Cytosine Tautomer Upon Complex Formation With (dien)M2+ (M=Pt, Pd)",

W. Brüning, I. Ascaso, E. Freisinger, M. Sabat and B. Lippert, Inorg.Chim.Acta, 39, 400 (2002).

 

“Metal-Stabilized Rare Tautomers of Nucleobases. 7. N1 and N3 Linkage Isomers of Neutral and Deprotonated Cytosine with trans-(CH3NH2)2PtII )",

W. Brüning, E. Freisinger, M. Sabat, R. K. O. Sigel and B. Lippert, Chem. Eur. J., 8, 4681 (2002).

 

“Simultaneous N7, O6-Binding of Guanine to Two Zinc Centers and Its Possible Biological Significance", F. Zamora and M. Sabat, Inorg. Chem., 41, 4976 (2002)

 

“Metal-Modified Base Pairs Involving Different Donor Sites of Purine Nucleobases: trans-[a2Pt(7,9-DimeG-N1)(9-EtGH-N7)]+ and trans-[a2Pt(7,9-DimeG-N1)(9-EtG-N7)]+ (a = NH3 or CH3NH2; 9-EtGH = 9-Ethylguanine; 7,9-DimeG = 7,9-Dimethylguanine). Possible Relevance to Metalated DNA Triplex Structures”, R.K.O Sigel, M. Sabat, E. Freisinger, A. Mower and B.Lippert, Inorg.Chem., 38, 1481(1999).
 

“Metal-Stabilized Rare Tautomers of Nucleobases. 6. Imino Tautomer of Adenine in a Mixed-Nucleobase Complex of Mercury(II)”, F. Zamora, M. Kunsman, M. Sabat, and B. Lippert, Inorg. Chem. 36, 1583 (1997).

“Model for a Platinated DNA Triplex:Watson-Crick and Metal-Modified Hoogsteen Pairing", I. Dieter-Wurm, M. Sabat, and B. Lippert, J. Am. Chem. Soc. 114, 357 (1992).

Molecular Modeling

“Structurally Rigid and OpticallyActive Dendrimers” Q.-S.Hu, V.Pugh, M.Sabat and L.Pu, J.Org.Chem., 64, 7528 (1999).

Quantum Chemistry

“The Effect of Metal Binding to the N7 Site of Purine Nucleotides on Their Structure, Energy, and Involvement in Base Pairing”, J.Sponer, M.Sabat, L.Gorb, J.Leszczynski,B.Lippert and P.Hobza, J.Phys.Chem. B, 104, 7535 (2000).

“Interaction of the Adenine-Thymine Watson-Crick and Adenine-Adenine Reverse Hoogsteen Base Pairs with Hydrated Group II a (Mg 2 +,Ca 2 +, Sr2 +, Ba 2 +) and Group II (Zn 2 +,Cd2+, Hg 2 +) Metal Cations. Absence of the Base Pair Stabilization by Metal-Induced Polarization Effects”, J. Sponer, M. Sabat,J.V. Burda, J. Leszczynski and P. Hobza, J. Phys. Chem. B, 103, 2528 (1999).

“Metal Ions in Non-Complementary DNA Base Pairs: an Ab Initio Study of Cu(I), Ag(I), and Au(I) Complexes with the Cytosine-Adenine Base Pair” J.Sponer, M.Sabat, J.V.Burda, J.Leszczynski, P.Hobza and B.Lippert, J.Biol.Inorg.Chem., 4, 537 (1999).

“Interaction Between the Guanine-Cytosine Watson-Crick DNABase Pair and Hydrated Group IIa (Mg 2 +,Ca 2 +, Sr2+, Ba 2 +) and Group IIb (Zn 2+, Cd2+, Hg 2 +) Metal Cations”J. Sponer, J. V. Burda, M. Sabat, J .Leszczynski and P. Hobza, J. Phys. Chem. A, 102, 5951(1998).

“Stabilization of the Purine.Purine.Pyrimidine DNA Base Triplets by Divalent Metal Ions”,J. Sponer, M. Sabat, J. V. Burda, A. M. Doody, J. Leszczynski and P.Hobza, J. Biomol. Struct. Dynamics, 16, 139 (1998).

 

(Molecular Structure Laboratory Homepage)