67 y/o M treated with colchicine for gout. Now with lower extremity weakness, normal CPK.
||ATPase histochemistry, pH 4.3||
||ATPase histochemistry, pH 4.3|
Down for Dx:
Neurogenic atrophy (colchicine neuropathy with denervation changes)
1) grouped atrophy in left figure, a sign of chronic denervation/reinnervation/denervation cycle
2) fiber type grouping in middle figure, also a sign of chronic denervation
3) target fibers in right figure, another sign of denervating disease