Ke Sheng's Research Home Page

Research Interests:

Deformable registration based on hyperpolarized 3He imaging and lobar segmentation

Quantum dots/Photofrin conjugate as the energy mediator to enhance radiation therapy

Probability density function based treatment planning

Adaptive radiation therapy

The role of radioprotector in stereotactic lung radiation therapy

Recent Publications:

 

 

1.The evolution for various matter perturbations in the expanding universe, Wenbin Lin, Ke Sheng    Communication in theoretical physics Vol 34 (2000) 173-178

 

2. Imaging dose management using multi-resolution in CT guided radiation therapy, Ke Sheng, Robert Jeraj,         T.R. Mackie, Bhudatt Paliwal. Phys. Med. Biol. 50 (2005) 1205-1219,

 

3. IMRT Dosimetry of the head and neck: A Comparison of Treatment Plans Using Linac-Based IMRT and Helical Tomotherapy, Ke Sheng, Janelle Molloy, Paul Read. Int. J. Radiation Oncology Biol. Phys., Vol. 65, No. 3, pp. 917–923, 2006,     

 

4. A Dosimetric Comparison of Non-coplanar IMRT versus Helical Tomotherapy for Nasal Cavity and Paranasal Sinus Cancer Ke Sheng, Janelle Molloy, James Larner, Paul Read. Radiotherapy and Oncology 2007, Pages 174-178

 

5. A computer simulated study of dose optimization based on lung tumor probability function obtained from long time dynamic MRI scan of human subject Ke Sheng, Jing Cai, Talissa Altes, James Brookeman, Paul Read. Medical Physics Journal 2006 Sep;33(9):3321-6,

 

6 .Evaluation of internal lung motion based on long time MRI scan Jing Cai, Paul Read, Janelle Molloy, Talissa. Altes, John Christopher, James Brookeman, Ke Sheng*. Phys. Med. Biol. 52 (2007) 365–373,

 

7. Dose as a function of liver volume and planning target volume in helical tomotherapy, intensity-modulated radiation therapy-based stereotactic body radiation therapy for hepatic metastasis Joseph Baisden, Ke Sheng, Janelle Molloy, James Larner, Paul Read. International Journal of Radiation Oncology • Biology • Physics 2006 Oct 1;66(2):620-5

 

8. A motion phantom study on helical tomotherapy: the dosimetric impacts of delivery technique and motion Brian Kanagaki, Paul Read, Janelle Molloy, James Larner, Ke Sheng* Phys. Med. Biol. 52 (2007) 243–255,

 

9. Is Daily CT image Guidance Necessary for Nasal Cavity and Nasopharyngeal Radiotherapy? An Investigation Based on Helical Tomotherapy Ke Sheng PhD Mok-Chung Jennifer Chow,Grant Hunter,Stanley Benedict,James M Larner MD,Paul W. Read MD PhD Journal of Applied Clinical Physics 2008 Jan 28;9(1): 36-46

 

10. MR Grid-Tagging using Hyperpolarized Helium-3 for Regional Quantitative Assessment of Pulmonary Biomechanics and Ventilation  J. Cai, T. A. Altes, G. W. Miller, Ke Sheng, P. W. Read, J. F. Mata, X. Zhong, G.D. Cates, Jr., E. E. de Lange, J. P. Mugler III, J. R. Brookeman Magn Reson Med. 2007 Aug;58(2):373-80

 

11. MR Grid-Tagging using Hyperpolarized Helium-3 for Assessment of Lung Motion  J. Cai, , P. W. Read, J. Larner, Ke Sheng*, International Journal of Radiation Oncology • Biology Vol. 68, No. 3, pp. 650–653, 2007,

 

12. Helical Tomotherapy in the Treatment of Central Nervous System Metastasis, Joseph M. Baisden, Stanley H. Benedict, Ke Sheng, Paul W. Read , James M. Larner, Neurosurgical Focus . (2007) Mar 15;22(3)  PMID 17608361

 

13. Dose as a function of lung volume and planned treatment volume in helical tomotherapy intensity-modulated radiation therapy-based stereotactic body radiation therapy for small lung tumors, Joseph Baisden, Davis Romney, Andrew Reish, Jing Cai, Ke Sheng, James Larner, Paul Read, International Journal of Radiation Oncology • Biology • Physics 2007 68(4): 1229-1237

 

14. Evaluation of Thoracic Spinal Cord Motion using Dynamic MRI Jing Cai1, Paul W Read1, Jason P. Sheehan2, Stanley H Benedict1, James M Larner1, Ke Sheng* Radiother Oncol. 2007 Sep;84(3):279-82.

 

15. Estimation of error in maximal intensity projection-based internal target volume of lung tumors: a simulation and comparison study using dynamic magnetic resonance imaging.Jing Cai, Ph.D., Paul Read, M.D., Ph.D., James Larner, M.D., Stanley Benedict, Ph.D., Ke Sheng*, Ph.D. International Journal of Radiation Oncology • Biology (2007) Nov 1;69(3):895-902

 

16. Evaluation of coplanar partial left breast irradiation using Tomotherapy-based Topotherapy, McIntosh, A., Read,   P., Khandelwal, S, Arthur D., Turner AB, Ruchala K., Olivera G, Jeswani, S, Sheng K*, Int J Radiat Oncol Biol Phys. 2008 Jun 1;71(2):603-10, PMID 18474316.

 

17. Semiconductor Nanoparticles as Energy Mediators for Photosensitizer-Enhanced Radiation Therapy Wensha Yang, Paul Read, James Larner, Jun Mi, Ke Sheng*, International Journal of Radiation Oncology • Biology 2008 72(3) 633-635, PMID 19014777

 

18. Novel FRET-Based Radiosensitization Using Quantum Dot-Photosensitizer Conjugates Yang  W., Read, P.W.,  Jun Mi,  Lamer, J.M.,  Benedict, S.H.,  Sheng , Ke*(Co-corresponding author), Helmke, B.P.  Signals, Systems and Computers, 2007. ACSSC 2007. 1861-1865

 

19. Reproducibility of Inter-fractional Lung Motion Probability Distribution Function (PDF) using Dynamic  MRI: Statistical Analysis, Jing Cai, Paul Read, Ke Sheng*, International Journal of Radiation Oncology • Biology (2008), Vol. 72, No. 4, pp. 1228–1235, PMID 18954717.

 

20. The effect of respiratory motion variability and tumor size on the accuracy of average intensity projection from four-dimensional computed tomography: an investigation based on dynamic MRI, Jing Cai, Paul Read, Stanley Benedict, Ke Sheng*, Medical Physics Journal (2008), 35(11) 4974-4981 PMID: 19070231

 

21. Imaging the Lung in Radiotherapy: Where 4D meets Multimodality Ke Sheng, Jing Cai, Bruce Libby, and Stanley Benedict, Review 23.   (Invited Review) Imaging Decisions MRI (2008) Volume 12, Issue 1 (p 25-31) 

 

22.   A small animal irradiation platform for outcome assessment of lung stereotactic radiosurgery Jing Cai, Talisa Altes, Jaime Mata, Ke Sheng* (Co-corresponding author), Paul Read, International Journal of Radiation Oncology • Biology (2009), 73(5), 1588-1595 PMID 19306756

 

23. Chest Wall Volume Receiving More than 30 Gy Predicts Risk of Severe Pain and/or Rib Fracture Following Lung Stereotactic Body Radiation Therapy Neal E. Dunlap, Jing Cai, Gregory B. Biedermann, Wensha Yang, Stanley H. Benedict, Ke Sheng, Tracey E. Schefter, Brian D. Kavanagh, James M. Larner, International Journal of Radiation Oncology • Biology. 2010 Mar 1;76(3):796-801.PMID: 19427740

 

24. The implication of non-cyclic intrafractional longitudinal motion in SBRT by TomoTherapy Wensha Yang, Ray Van Ausdal, Paul Read, James Larner, Stan Benedict, Ke Sheng* Physics in medicine and biology 54 (2009) 2875-2884 PMID 19384001

 

25. Dynamic MRI of Grid-Tagged Hyperpolarized Helium-3 for the Assessment of Lung Motion during Breathing Jing Cai, Ke Sheng, Stanley H. Benedict, Paul W. Read, James M. Larner,

John P. Mugler III, Eduard E. de Lange, Gordon D. Cates Jr. , G. Wilson Miller, International Journal of Radiation Oncology • Biology 2009 Sep 1;75(1):276-84. PMID: 19540059

 

26. Tracking brain motion during the cardiac cycle using spiral cine-DENSE MRI, Xiaodong Zhong , David Schlesinger , Jason Sheehan , Craig Meyer , Frederick Epstein , James Larner , Paul Read , Stanley Benedict , Ke Sheng, Jing Cai. Medical Physics Journal 2009 Aug;36(8):3413-9  PMID: 19746774.

 

27. Tumor Cell Survival Dependence on the Helical Tomotherapy, Continuous Arc and Segmented Dose Delivery Wensha Yang, Li Wang, James Larner,  Paul Read, Stan Benedict, Ke Sheng*. Physics in Medicine and Biology 2009 54(21):6635-43. PMID: 19826199

 

28. Intensity modulated radiation therapy (IMRT) outcomes for oropharyngeal squamous cell carcinoma patients stratified by p16 status. Asal Shoushtari MD Mathew Meeneghan, Ke Sheng, Christopher A Moskaluk, Christopher Y Thomas, James F Reibel, Paul A Levine, Mark J Jameson, Kimberly Keene, Paul W Read, Cancer. 2010 Jun 1;116(11):2645-54 PMID: 20225325

 

29. Helical TomoTherapy-based STAT SBRT: Dosimetric Evaluation for a Real Time SBRT Treatment Planning and Delivery Program Neal Dunlap, Alyson McIntosh, Ke Sheng, Stanley Benedict, Benton Turner, Asal Shoushtari, Jason Sheehan, David R. Jones, James M. Larner,  Paul W. Read, in press by Medical Dosimetry (2010)

 

30. Dunlap NE, Larner JM, Read PW, Sheng K, David Jones. Size Matters: A Comparison of T1 and T2     Peripheral Non-small Cell Lung Cancers Treated With Stereotactic Body Radiation Therapy (SBRT). The Journal of Thoracic and Cardiovascular Surgery.  2010 Sep;140(3):583-9.

 

31. Cai J,  McLawhorn R, Read PW, Larner J, Benedict SH., Sheng K*. Effects of breathing variation on the respiratory gating window internal target volume. Med Phys. 2010 Aug;37(8):3927-34.

 

32. Comparison of Elekta VMAT with helical tomotherapy and fixed field IMRT: Plan quality, delivery efficiency and accuracy Rao M, Yang WS, Chen F., Sheng K et al Med. Phys. (37)3 (2010) pp 1350-1359

 

33. Functional treatment planning based on hyperpolarized He MRI and tomotherapy, Jing Cai, Stanley Benedict, Ke Sheng*, Accepted Medical Dosimetry (2010)

 

34. Quantification of the simultaneous integrated boost using RapidArc Wensha Yang, Ryan Jones, Stanley Benedict, Ke Sheng*, In Press PMB (2010)

 

35. Helical TomoTherapy-based STAT SBRT: Dosimetric Evaluation for a Real Time SBRT Treatment Planning and Delivery Program Medical Dosimetry Neal Dunlap, Ke Sheng, Wensha Yang, Paul Read Med Dosim. 2010 Winter;35(4):312-9.

 

36. Apoptosis induced by the semiconductive nanoparticle/Photofrin conjugate in radiotherapy Li Wang, Wensha Yang, Paul Read, James Larner, Ke Sheng*, Nanotechnology 21 (2010) 475103 (7pp).

 

37. Dose verification using tomotherapy CT detector array Ke Sheng, Wensha Yang, Ryan Jones, Paul Read accepted International Journal of Radiation Oncology Biology and Physics (2011)

 

38. SRT and SBRT: Current practices for QA dosimetry and 3D S H Benedict, J Cai, B Libby, M Lovelock, D Schlesinger, K Sheng, and W Yang Journal of Physics:Conference Series 250 (2010) 012057-012068

 

39. Use of MVCT with Image Registration for HDR Treatment Planning of an Oral Tongue    Cancer Using a Custom Oral Mold Applicator with Embedded Lead Shielding, B. Libby, K. Sheng, R. McLawhorn, A. McIntosh, R. van Ausdal, A. Martof, P. Read accepted by Brachytherapy (2011).

 

40. Dosimetric comparison of 6 mv and 15 mv single arc rapidarc to helical tomotherapy for the treatment of pancreatic cancer  Jing Cai, Jinbo Yue, Robert McLawhorn, Wensha Yang, Krishni Wijesooriya, Neal E. Dunlap, Ke Sheng, Fang-fang Yin, Stanley H. Benedict Medical Dosimetry, In press (2011)

 

41. Quantification of regional lung ventilation from tagged hyperpolarized Helium-3 MRI. K. Ding, W. Miller, K. Cao, G. Christensen, J. Reinhardt, S. Benedict, B. Libby, K. Sheng*, IEEE-ISBI 2011

 

 

B.            Paper submitted

 

42. Ryan Jones, Paul Read, Ke Sheng  Class Solution of Post-Mastectomy Radiation Therapy Using Tomotherapy, under revision, Radiotherapy and Oncology 2010  

 

43. Non-coplanar tomotherapy Wensha Yang, Ryan Jones, Paul Read, James Larner, Ke Sheng,

 

44. The impact of variation in daily dose on the tumor control probability, Siddharth Saraiya, Wensha Yang, Paul Read, Ke Sheng Under revision,  Physics in Medicine and Biology

 

45. Integrated optimization for central nervous system irradiation Wensha Yang, Paul Read, James Larner, Ke Sheng, submitted to Practical Radiation Oncology

 

Book Chapters:

 1. Helical TomoTherapy for head and neck cancer, a case study. Ke Sheng, Paul Read, in IGRT: A Clinical Perspective, editor: Arno J. Mundt and John C. Roeske, Publisher B.C. Decker of Toronto, 2009, in press

 2. Nanomaterials for Radiation Therapy, Ke Sheng, Wensha Yang, in Nanomaterials for the Life     Sciences, edited by Challa Kumar, publisher Wiley, 2009, in press