to the Timko laboratory. Our work explores the relationship between the genomic
content of vascular plants and their capacity to grow, differentiate, and respond
to an environment replete with a large variety of biotic and abiotic challenges
and stresses. Our studies rely on an integrative approach that uses biochemistry,
genome sequence information, bioinformatics, and gene expression profiling to
uncover basic information about plant cellular function and development.
main areas of research currently underway in the laboratory include the functional
genomics of cowpea (Vigna unguiculata L.) an important African legume.
In these studies we are using genomic wide sequence data for molecular marker
development and microarray analysis to examine global gene expressionas strategies
for the genetic improvement of cowpea. We also study the molecular genetics of
host plant and non-host plant resistance to parasitism by the root hemiparasite
Striga gesnerioides and its relatives. These studies include an examination
of the evolution of parasitism in the Orobanchaceae (Striga, Orobanche, and Tryphysaria) as a way of determining what makes a parasitic
angiosperm unique. Finally, we are studying the transcription regulation of alkaloid
biosynthesis in tobacco (Nicotiana tabacum L.) where we are interested
in defining the cross-talk between various signal transduction pathways that regulate
these secondary compounds during development and as part of natural defense pathways
to insect and herbivore attack.
laboratory also has a number of ongoing collaborative projects with faculty in
the University of Virginia School of Medicine were we apply our knowledge of plant
and human biology for the production of novel human therapeutics and nutraceuticals.
Notice: This Website was designed and is maintained by Joanne Lane. Copyright (c) 2009 The Timko Laboratory at the University of Virginia. Contents may not be copied and/or published electronically or in print without prior written consent. All rights reserved.