Karen Martin

University of Virginia
Department of Microbiology
1300 Jefferson Park Avenue
Room 2-25 Jordan Hall
Charlottesville, VA 22908
Phone: 434-924-5341 (lab)
FAX: 434-982-0689
email: km2b@virginia.edu



My project involves the study of focal adhesion dynamics. Focal adhesions are adhesive structures that link a cell to its extracellular matrix. These structures are mediated by the transmembrane integrin receptors which bind directly to matrix on the outside of the cell and serve as a platform for the assembly of numerous structural and signaling proteins on the cytoplasmic face of the membrane. In a migrating cell, focal adhesions are dynamic. New structures must be formed at the leading edge of the cell and old structures at the rear of the cell must be released to allow the cell to move forward. I am using "real-time" fluorescent microscopy to study the movement of proteins into and out of focal adhesions in living cells.



Liu Y, Loijens JC, Martin KH, Karginov AV, Parsons JT. The Association of ASAP1, an ADP Ribosylation Factor-GTPase Activating Protein, with Focal Adhesion Kinase Contributes to the Process of Focal Adhesion Assembly. Mol Biol Cell. 2002 Jun;13(6):2147-56

Martin KH, Slack JK, Boerner SA, Martin CC, Parsons JT. Integrin connections map: to infinity and beyond. Science. 2002 May 31;296(5573):1652-3

Martin KH, Boerner SA, Parsons JT. Regulation of focal adhesion targeting and inhibitory functions of the FAK related protein FRNK using a novel estrogen receptor "switch". Cell Motil Cytoskeleton. 2002 Feb;51(2):76-8

Parsons, J.T., K.H. Martin, J.K. Slack, J.M. Taylor, and S.A. Weed. 2000. "Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement." Oncogene. 19:5606-13.

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