Representative Publications

Kanner, S.B., A.B. Reynolds, R.R. Vines, and J.T. Parsons. 1990. Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc. Natl. Acad. Sci. USA. 87: 3328-3332.

Parsons, J.T. 1990. Closing the gap in a signal transduction pathway. Trends in Genetics. 6: 169-171.

Kanner, S.B., A.B. Reynolds, and J.T. Parsons. 1991. Tyrosine phosphorylation of 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-transformed cells. Mol. Cell. Biol. 11: 713-720.

Bouton, A.H., S.B. Kanner, R.R. Vines, H-C. R. Wang, J.B. Gibbs, and J.T. Parsons. 1991. Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine phosphorylated cellular proteins with GTPase activating protein. Mol. Cell. Biol. 11: 945-953.

Kanner, S.B., A.B. Reynolds, H-C.R. Wang, R.R. Vines, and J.T. Parsons. 1991. The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110. EMBO J. 10: 1689-1698.

Wu, H., A.B. Reynolds, S.B. Kanner, R.R. Vines, and J.T.Parsons. 1991. Identification and characterization of a novel cytoskeleton-associated pp60src substrate. Mol. Cell. Biol. 11: 5113-5124.

Bouton, A.H., S.B. Kanner, R.R. Vines, and J.T. Parsons. 1991. Tyrosine phosphorylation of three cellular proteins correlates with transformation of Rat 1 cells by pp60src. Mol. Carcinogen. 4: 145-152.

Cobb, B.S., D.M.Payne, A.B. Reynolds and J.T. Parsons. 1991. Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated Tyrosine (Tyr-527). Mol. Cell. Biol. 11: 5832-5838.

Flynn, D.C., M.D. Schaller, and J.T. Parsons. 1992. Tyrosine phosphorylation of a 120 000 dalton membrane-associated protein by the neural form of pp60c-src, pp60c-src+. Oncogene 7: 579-583.

Schaller, M.D., C.A.Borgman, B.S. Cobb, R.R. Vines, A.B. Reynolds, and J.T. Parsons. 1992. PP125FAK, a structurally distinctive protein tyrosine kinase associated with focal adhesions. Proc. Natl. Acad. Sci. USA, 89: 5192-5196.

Maa, M-C., L.K. Wilson, J.S. Moyers, R.R. Vines, J.T. Parsons, and S.J. Parsons. 1992. P75, an EGF sensitive substrate of the c-src tyrosine kinase. Oncogene 7: 2429-2438.

Lipfert, L., B. Haimovich, M.D. Schaller, B.S. Cobb, J.T. Parsons, J.S. Brugge, 1992. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets. J. Cell Biol. 119: 905-912.

Bouton, A.H. and J.T. Parsons. 1992. Retrovirus and cancer: models for cancer in animals and man. Cancer Investigation. 11:70-79.

Farina, S.F., J.L. Huff, and J.T. Parsons. 1992. Mutations within the 5' half of the avian retrovirus MC29 v-myc gene alter or abolish transformation of chicken embryo fibroblasts and macrophages. J. Virol. 66:2698-2708.

Kornberg, L., H. S. Earp, J.T. Parsons, M.D. Schaller, and R.L. Juliano. 1992. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion associated tyrosine kinase. J. Biol. Chem. 267:23439-23442.

Ely, C.M., S.J. Parsons, and J.T. Parsons. 1992. Immunological methods for the detection of phosphotyrosine containing proteins in neural tissues. Neuroprotocols 1:177-184.

Parsons, J.T. and S.J. Parsons. 1992. Protein tyrosine kinases and their relationship to oncogenes. Advances in Oncology (Eds: Devita, V.T., Hellman, S., and Rosenberg, S.A.) J. B. Lippincott. pp 3-17.

Guy, C.T., M.A. Webster, M.D.Schaller, J.T. Parsons, R.D. Cardiff and W.J. Muller. 1992. Expression of the c-neu proto-oncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc. Natl. Acad. Sci. USA. 89: 10578-10582.

Schaller, M.D., C.A. Borgman, and J.T. Parsons. 1993. Autonomous expression of a noncatalytic domain of the focal adhesion associated protein tyrosine kinase pp125FAK. Mol Cell. Biol. 13: 789-791.

Wu, H. and J.T. Parsons. 1993. Cortactin, an 80/85-killodalton pp60src substrate , is a filamentous actin-binding protein enriched in the cell cortex. J. Cell Biol. 120:1417-1426.

Schaller, M.D., A.H. Bouton, D.C. Flynn, and J.T. Parsons. 1993. Identification and characterization of novel substrates for protein tyrosine kinases. Prog. Nucl. Acids Res. and Mol. Biol. (eds: W.E.Cohn and K. Moldave) 44:205-227.

Huff, J.L., M.A. Jelinek, C.A. Borgman, T.J. Lansing, and J.T. Parsons. 1993. The protooncogene c-sea encodes a transmembrane protein tyrosine kinase related to the MET/hepatocyte growth factor/scatter factor receptor. Proc. Natl. Acad. Sci. USA 90:6140-6144.

Schaller, M.D. and J.T. Parsons. 1993. Focal adhesion kinase: an integrin-linked protein tyrosine kinase. Trends in Cell Biology. 3:258-262.

Cobb, B.S. and J.T. Parsons. 1993. Regulation of the cellular src protein tyrosine kinase: interactions of the carboxyl terminal sequences residing between the kinase domain and tyrosine-527. Oncogene. 8:2897-2903.

Turner, C.E., M.D. Schaller, and J.T. Parsons. 1993. Tyrosine phosphorylation of the focal adhesion kinase pp125FAK during development: relation to paxillin. J. Cell Science 105:637-645.

Hildebrand, J.D., M.D. Schaller and J.T. Parsons. 1993. Identification of sequences required for the efficient localization of the focal adhesion kinase,pp125FAK, to cellular focal adhesions. J. Cell Biol. 123:993-1005.

Flynn, D.C., T-H. Leu, A.B. Reynolds and J.T. Parsons. 1993. Identification and sequence analysis of cDNAs encoding a 110 kilodalton actin filament-associated pp60src substrate. Mol. Cell. Biol. 13:7892-7900.

Faris, M., F. Gaskin, J.T. Parsons and S.M. Fu. 1994. CD40 signaling pathway: Anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein. J. Exp. Med. 179:1923-1931.

Cobb, B.S., M.D. Schaller, T-H. Leu and J.T. Parsons. 1994. Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK. Mol. Cell. Biol. 14: 147-155.

Schaller, M.D., J.D. Hildebrand, J.D. Shannon, J.W. Fox, R.R. Vines, and J.T. Parrsons 1994. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol. Cell. Biol. 14:1680-1688.

Miglarese, M. R., J. Mannion-Henderson, H. Wu, J.T. Parsons, and T.P. Bender. 1994. The protein tyrosine kinase substrate cortactin is differently expressed in murine B lymphoid tumors. Oncogene 9:1989-1997.

Shattil, S.J., B. Haimovich, M. Cunningham, L. Lipfert, J.T. Parsons, M. Ginsberg, and J. Brugge. 1994. Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signalling through integrin and agonist receptors. J. Biol. Chem. 20:14738-14745.

Schaller, M.D. and Parsons, J.T. 1994. Focal adhesion kinase and associated proteins. Current Opionion in Cell Biology 6:705-710.

Marengere, L.E.M., Z. Songyang, G.D. Gish, M.D. Schaller, J.T. Parsons, M.J. Stern, L.C. Cantley, and T. Pawson. 1994. SH2 domain specificity and activity modified by a single residue. Nature 369: 502-505.

Parsons, J.T., M.D. Schaller, J. Hildebrand, T.-H. Leu, A. Richardson, and C. Otey. 1994. Focal adhesion kinase: structure and signalling. In Cell Biology of Cancer (Eds. David Glover, Alan Hall and Nick Hastie) J. Cell Sci. 18: 109-113.

Richardson, A. and J.T. Parsons. 1995. Review articles: Signal transduction through integrins: a central role for focal adhesion kinase? BioEssays 17:229-236.

Schaller, M.D. and J.T.Parsons. 1995. pp125fak-dependent tyrosine phosphorylation of paxillin creates a high affinity binding site for Crk. Mol. Cell. Biol. 15:2635-2645.

Schaller, M.D., C.A. Otey, J.D. Hildebrand, and J.T. Parsons. 1995. Focal adhesion kinase and paxillin bind to peptides mimicking integrin cytoplasmic domains. J. Cell. Biol. 130: 1181-1187.

Hildebrand, J.D., M.D. Schaller, and J.T. Parsons. 1995. Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxylterminal domain of focal adhesion kinase. Mol. Bio. Cell. 6:637-647.

Huff, J.L. and J.T. Parsons. 1995. SEA receptor PTK. The Protein Kinase Factsbook. (Eds. D.G. Hardy and S. Hanks). 221-222.

Chen, H.-C., J.T. Parsons, J.D. Hildebrand, M.D. Schaller and J.-L. Guan. 1995. Interaction of FAK with cytoskeletal protein talin. J. Biol. Chem. 270:16995-16999.

Huff, J.L., M.A. Jelinek, T.A. Jamieson and J.T. Parsons. 1996. Expression and maturation of the cellular sea receptor, a member of the hepatocyte growth factor (HGF) receptor family of protein tyrosine kinases. Oncogene 12:299-307.

Parsons, J.T. 1996. Integrin-mediated signalling: regulation by protein tyrosine kinase and small GTP-binding proteins. Curr. Opin. Cell. Biol. 8:146-152.

Richardson, A. and J.T. Parsons. 1996. A mechanism for the regulation of the adhesion-associated protein tyrosine kinase pp125FAK. Nature 380:538-540.

Medico, E., A.M. Mongiovi, J. Huff, M.A. Jelinek, A. Follenzi, G. Gaudino, J.T. Parsons and P.M. Comoglio. 1996. The tyrosine kinase receptors Ron and Sea control Ascattering@ and morphogenesis of liver progenitor cells in vitro. Mol. Biol. Cell. 7:495-504.

Hildebrand, J.D., J.M. Taylor and J.T. Parsons. 1996. An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Mol. Cell. Biol. 16:3169-3178.

Harte, M.T., J.D. Hildebrand, M.R. Burnham, A.H. Bouton and J.T. Parsons. 1996. p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase. J. Biol. Chem. 271:13649-13655.

Chen, H.-C., J.T. Parsons, J.D. Hildebrand, M.D. Schaller and J.-L. Guan. 1996. Interaction of FAK with cytoskeletal protein talin. J. Cell. Biol. 270:16995-16999.

Malik, R.K. and J.T. Parsons. 1996. Integrin-mediated signaling in normal and malignant cells: a role of protein tyrosine kinases. Biochim. Biophys. Acta 1287:73-76.

Burnham, M.R., M.T. Harte, A. Richardson, J.T. Parsons and A.H. Bouton. 1996. The identification of p130cas-binding proteins and their role in cellular transformation. Oncogene 12:2467-2472.

Malik, R.K. and J.T. Parsons. 1996. Integrin-dependent activation of the p70 ribosomal S6 kinase signaling pathway. J. Biol. Chem. 271:29785-29791.

Richardson, A., J.D. Shannon, M.D. Schaller, and J.T. Parsons. 1997. Identification of integrin-stimulated sites of serine phosphorylation in FRNK, the separately expressed C-terminal domain of focal adhesion kinase: a potential role for protein kinase A. Biochem. J. 324:141-149.

Parsons, J.T. and S.J. Parsons. 1997. Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways. Current Opinion in Cell Biology 9:187-192.

Xiong, W-C and J.T. Parsons. 1997. Induction of apoptosis following expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase. J. Cell Biology 139:529-539.

Richardson, A., R.K. Malik, J.D. Hildebrand and J.T. Parsons. 1997. Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by co-expression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation. Mol. Cell. Biol. 17:6906-6914.

Taylor, J.M., A. Richardson and J.T. Parsons. 1998. Modular domains of focal adhesion-associated proteins. Curr. Top. Microbiol. Immunol. 228:135-163.

Lacoste, J., A. Ma and J.T. Parsons. 1998. Assay and purification of focal adhesion kinase. Methods in Enzymol. 289:89-102.

Taylor, J.M., J.D. Hildebrand, C.P. Mack, M.E. Cox and J.T. Parsons. 1998. Characterization of Graf, the GTPase-activating protein for Rho associated with focal adhesion kinase. J. Biol. Chem. 273:8063-8070.

Xiong, W-C., M. Macklem and J.T. Parsons. 1998. Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein. J. Cell Sci. 111:1981-1991.

Weed, S.A., Y. Du and J.T. Parsons. 1998. Translocation of cortactin to the cell periphery is mediated by the small GTPase rac1. J. Cell Sci. 111:2433-2443.

Du, Y., S.A. Weed, W.-C. Xiong, T.D. Marshall and J.T. Parsons. 1998. Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. Mol. Cell Biol. 18: 5838-5851.

Sheffield, P.J., U. Derewenda, J. Taylor, J.T. Parsons and Z.S. Derewenda. 1999. Expression, purification and crystallization of a BH domain from the GTPase regulatory protein associated with focal adhesion kinase. Acta Cryst. D55: 356-359.

Taylor, J.M., M.M. Macklem and J.T. Parsons. 1999. Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho. J. Cell Sci. 112: 231-242.

Lakkakorpi, P.T., I. Nakamura, R.M. Nagy, J.T. Parsons, G.A. Rodan and L.T. Duong. 1999. Stable Association of PYK2 and p130Cas in osteoclasts and their co-localization in the sealing zone. J. Biol. Chem. 274: 4900-4907.

Nolan, K., J. Lacoste and J. T. Parsons. 1999. Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase. Mol. Cell. Biol. 19: 6120-6129.

Slack, J.K., A.D. Catling, S.T. Eblen, M.J. Weber and J.T. Parsons. 1999. C-Raf-mediated inhibition of epidermal growth factor-stimulated cell migration. J. Biol. Chem. 274:27177-27184.

Wahl, R.C., R.Y. Hsu, J.L. Huff, M.A. Jelinek, K. Chen, P. Courchesne, S.D. Patterson, J.T. Parsons and A.A. Welcher. 1999. Chicken macrophage stimulating protein is a ligand of the receptor protein-tyrosine kinase sea. J. Biol. Chem. 274:26361-26368.

Schaller, M.D., J.D. Hildebrand and J.T. Parsons. 1999. Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of src kinases. Mol. Biol. Cell. 10:3489-3505.

Horwitz, A.L., and J.T. Parsons. 1999. Cell Migration-Movin' On. Science 286:1102-1103.

Harte, M.T., M. Macklem, C.L. Weidow, J.T. Parsons, and A.H. Bouton. 2000. Identification of two focal adhesion targeting sequences in the dapter molecule p130Cas. Biochem. Biophys. Acta. 1499:34-48.

Taylor, J.M., J.D. Rovin and J.T. Parsons. 2000. A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes. J. Biol. Chem. 275:19250-19257.

Weed, S.A., A.V. Karginov, D.A. Schafer, A.W. Kinley, J.A. Cooper and J.T. Parsons. 2000. Cortactin Localization to Sites of Actin Assembly in Lamellipodia Requires Interactions with F-actin and the Arp2/3 Complex. J. Cell Biol. 151:29-40.

Longenecker, K.L., B. Zhang, R. Derewenda, P.J. Sheffield, Z. Dauter, J.T. Parsons, Y. Zheng and Z.S. Derewenda. 2000. Structure of the BH Domain from Graf and its implications for Rho GTPase recognition. J. Biol. Chem. 275:38605-38610.

Parsons, J.T., K.H. Martin, J.K. Slack, J.M.Taylor and S.A. Weed. 2000. Focal Adhesion Kinase: a Regulator of focal adhesion dynamics and cell movement. Oncogene. 19:5606-5613.

Rovin, J.D., H.F. Frierson, W. Ledinh, J.T. Parsons and R.B. Adams. 2001. Expression of focal adhesion kinase in normal and pathologic human prostate tissues. Revised and submitted to Cancer Research.

Ma, A., A. Richardson, E. Schaefer and J.T. Parsons. 2001. Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role of modulating binding to p130Cas. Mol. Biol. Cell. 12:1-12.

Weaver, A.M., A.V. Karginov, A.W. Kinley, S.A. Weed, Y. Li, J.T. Parsons and J.A. Copper. 2001 Cortactin Promotes and stabilizes ARP2/3-induced actin filament network. Current Biology 11:1-20.

Slack, J.K., R.B. Adams, J.D. Rovin, C.E. Stoker and J.T. Parsons. 2001. Alterations in the focal adhesion kinase/Src signal transduction pathway correleate with increased migratory capacity of prostate carcinoma cells. Oncogene 20:1152-1163.

Taylor, J.M., C.P. Mack, K. Nolan, C.P. Regan, G.K. Owens, and J.T. Parsons. 2001. Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells. Mol. Cell. Biol. 21:1565-1572.

Haskell MD, Slack JK, Parsons JT, Parsons SJ. c-Src tyrosine phosphorylation of epidermal growth factor receptor, P190 RhoGAP, and focal adhesion kinase regulates diverse cellular processes. Chem Rev. 2001 Aug;101(8):2425-40

Weed SA, Parsons JT. Cortactin: coupling membrane dynamics to cortical actin assembly.
Oncogene. 2001 Oct 1;20(44):6418-34.

Martin KH, Boerner SA, Parsons JT. Regulation of focal adhesion targeting and inhibitory functions of the FAK related protein FRNK using a novel estrogen receptor "switch". Cell Motil Cytoskeleton. 2002 Feb;51(2):76-8

Webb DJ, Parsons JT, Horwitz AF. Adhesion assembly, disassembly and turnover in migrating cells - over and over and over again. Nat Cell Biol. 2002 Apr;4(4):E97-E100.

Martin KH, Slack JK, Boerner SA, Martin CC, Parsons JT. Integrin connections map: to infinity and beyond. Science. 2002 May 31;296(5573):1652-3

Liu Y, Loijens JC, Martin KH, Karginov AV, Parsons JT. The Association of ASAP1, an ADP Ribosylation Factor-GTPase Activating Protein, with Focal Adhesion Kinase Contributes to the Process of Focal Adhesion Assembly. Mol Biol Cell. 2002 Jun;13(6):2147-56

Rovin JD, Frierson HF Jr, Ledinh W, Parsons JT, Adams RB. Expression of focal adhesion kinase in normal and pathologic human prostate tissues. Prostate. 2002 Oct 1;53(2):124-32.