P.O. Box 400319
fax:
(434) 924-3710
Office:
Room 129 Chemistry
Positions and Employment
Assistant
Professor, University
of Virginia,
Charlottesville,
VA
July 2005-present
Department of
Chemistry and Neuroscience Graduate Program
Research interests:
· Detection of
dopamine, adenosine, and serotonin
using electrochemical sensors
· Development of
new carbon nanotube-basedbiosensors
· Rapid-sampling
microdialysis with capillary
electrophoresis detection for monitoring
neurotransmitter changes
during
behavior
Postdoctoral
Researcher, University
of Michigan,
Ann
Arbor, MI
2003-2005
Advisors: Robert
Kennedy (Chemistry) and Terry Robinson (Psychology)
Research
topic: Capillary
electrophoresis analysis of microdialysis samples for
the detection
of rapid amino acid changes in the brain
Education
Ph.D.,
Chemistry (Analytical), University
of North Carolina,
Chapel Hill, NC
2003
Advisor: Mark Wightman
Dissertation: Electrochemical
detection of chemical dynamics in the rat brain
B.S.,
Chemistry, University
of Delaware,
Newark,
DE
1998
Honors
degree, summa
cum laude
Research
Advisor: Murray Johnston
Undergraduate thesis: Secondary
structure of oligonucleotides probed by MALDI
Current Grants and Funding
National
Institutes
of Health,
National Institute of Mental Health, 7/15/09-5/31/14, $1,818,346
1R01MH085159: “Real-time measurements of neurotransmission in
Drosophila
melanogaster”
Eli Lilly Young Investigator Award,
Sept. 2007-Sept. 2009, $100,000
National Science Foundation,
Feb. 2007-Jan. 2012, $550,000
“CAREER: Carbon nanotube modified microelectrodes for insect
neurotransmitter detection”
Completed Funding
National
Institutes of Health, National Institute of Biomedical Imaging
and Bioengineering, Aug. 2007-July 2009, $275,000
R21: “An electrochemical adenosine sensor for in vivo applications”
Eli Lilly Young Investigator Award,
Sept. 2007-Sept. 2009, $100,000
American Heart Association,
July 2007- June 2009, $132,000
“Mechanisms of adenosine formation during ischemia”
Distinguished
Young
Investigator Award, Fund for
Excellence in Science and
Technology, University
of Virginia,
July 1,
2006-June 30, 2007, $50,000
“Monitoring
fast neurochemical changes using
capillary electrophoresis with electrochemical detection”
Jeffress
Memorial
Trust, Jan.
1-Dec.31, 2006, $25,000
“Development
of an electrochemical adenosine sensor”.
Professional
Service
Journal Advisory Board,
The Analyst
2008-2010
NSF Review Panel
2008
Refereed Publications
From work done at
Virginia:
11.)
T. L. Vickrey, B. Condron, B.J. Venton. Detection of endogenous dopamine changes in
Drosophila using fast-scan cyclic voltammetry.
Analytical Chemistry. DOI:
10.1021/ac901638z
10.)
G. Shambat, A. Deberardinis, P. Reinke, B.J.
Venton, L. Pu, J. Bean, B. Chen, J. Tour.
Addition Reaction and Characterization of
Chlorotris(triphenylphosphine)iridium(I) on Silicon(111) Surfaces. Applied Surface Science. 2009, 255,
8533-8538.
9.)
S.E. Cooper and B.J. Venton. Fast-scan
cyclic voltammetry for the detection of tyramine and octopamine. Analytical
Bioanalytical Chemistry 2009, 394, 329-336.
8.)X.
Borue, S.E. Cooper, J. Hirsh, B. Condron, B.J.
Venton. Quantitative evaluation of
serotonin release and reuptake in Drosophila.
Journal Neuroscience Methods. 2009,
179, 300-308. NIHMSID # 112632
7.)
M.L. Huffman and B.J. Venton. Carbon
fiber microelectrodes for in vivo
applications. Analyst, 2009,
134, 18-24. NIHMS#110526 Pubmed
i.d.#
19082168
6.)
M.L. Huffman and B.J. Venton. Electrochemical
properties of different carbon-fiber
microelectrodes using fast-scan cyclic voltammetry.
Electroanalysis.
2008, 20, 2422-2428.
5.)
C. B. Jacobs, T.L. Vickrey, and B.J.
Venton. Measuring chemical events in
neurotransmission. Wiley Encyclopedia of
Chemical Biology, 2009, 3, 319-330.
4.)
A.M. Strand and B.J. Venton. Flame
etching enhances the sensitivity of
carbon-fiber microelectrodes. Analytical
Chemistry, 2008, 80,
3708–3715.
3.)
S. Cechova and B.J. Venton. Transient
adenosine efflux in the rat caudate-putamen.
Journal of Neurochemistry, 2008,
105, 1253-1263.
2.)
B.E. Kumara Swamy and B.J. Venton. Carbon
nanotube-modified microelectrodes for
simultaneous detection of dopamine and serotonin in vivo. Analyst, 2007, 132,
876-894.
*
This article was highlighted in Chemical Technology, 2007,
4,
T66.
1.)
B.E. Kumara Swamy and B.J. Venton. Subsecond
detection of physiological adenosine
concentrations using fast-scan cyclic voltammetry.
Analytical
Chemistry, 2007, 79, 744-750.
Work Previous to Virginia: (Note: published under
both Venton and Trafton.)
15.) B.J. Venton
and R.M. Wightman. Pharmacologically
induced, subsecond dopamine transients in
the caudate-putamen of the anesthetized rat.
Synapse, 2007, 61, 37-39.
14.) B.J. Venton,
R.T. Kennedy, T.E. Robinson, S. Maren. Dynamic increases in
glutamate and GABA in the basolateral
amygdala during acquisition and expression of conditioned fear. European
Journal of Neuroscience, 2006,
12, 3391-3398.
13.) B.J.
Venton, P.E.M. Phillips, W.C.
Wetsel, D. Gitler, G. Augustine, P. Greengard, R.M. Wightman. Cocaine increases dopamine release by
mobilization of a synapsin-dependent reserve pool.
Journal
of Neuroscience, 2006, 26,
3206-3209.
12.) D. Gitler, J.
Feng, Y. Takagishi, V.M.
Pogorelov, R.M. Rodriguiz; B.J. Venton, P.E.M.
Phillips, Y. Ren, H.-T.
Kao, R.M. Wightman, P. Greengard, P, W.C. Wetsel, G.J. Augustine. Synaptic vesicle trafficking and drug
addiction in synapsin triple knockout mice.
Cell
Biology of Addiction, 2006,
341-359.
11.) C.J.
Watson, B.J. Venton, R.T.
Kennedy. In vivo
measurements of neurotransmitters by microdialysis
sampling. Analytical Chemistry,
2006,
78, 1391-1399.
10.) B.J. Venton,
T.E. Robinson, R.T. Kennedy. Transient changes in
nucleus accumbens amino acid
concentrations correlate with individual responsivity to the predator
fox odor
2,5-dihydro-2,4,5-trimethylthiazoline. Journal of Neurochemistry 2006,
96, 236-246.
9.) B.J.
Venton, H. Zhang, P.A. Garris, D.
Sulzer, P.E.M. Phillips, R.M. Wightman.
Real-time decoding of dopamine neurotransmission in the
caudate-putamen
during tonic and phasic firing. Journal
of Neurochemistry, 2003, 87, 1284-1295.
8.) B.J.
Venton and R.M. Wightman. Psychoanalytical
electrochemistry: dopamine
and behavior. Analytical
Chemistry, 2003,
75, 414A-421A.
7.) D.L.
Robinson, B.J. Venton, M.L. Heien,
R.M. Wightman. Detecting subsecond
dopamine release with fast-scan cyclic voltammetry in vivo. Clinical
Chemistry, 2003, 49, 1763-1773.
6.) P.A.
Garris, E.A. Budygin, P.E.M. Phillips, B.J.
Venton, D.L. Robinson, B.P. Bergstrom, G.V. Rebec, R.M. Wightman. A role for presynaptic mechanisms in the
actions of nomifensine and haloperidol. Neuroscience,
2003, 118,
819-829.
5.) B.J.
Venton, D.J. Michael, R.M.
Wightman. Correlation of local changes
in extracellular oxygen and pH that accompany dopaminergic terminal
activity in the rat caudate-putamen.
Journal
of Neurochemistry, 2003, 84,
373-381.
4.) K.P.
Troyer, M.L. Heien, B.J. Venton,
R.M. Wightman. Neurochemistry and
electroanalytical probes. Current
Opinion in Chemical Biology, 2002, 6, 696-703.
3.) B.J.
Venton, K.P. Troyer, R.M.
Wightman. Response times of carbon fiber
microelectrodes to dynamic changes in catecholamine concentration. Analytical Chemistry, 2002,
74, 539-546.
2.) D.L.
Robinson, P.E.M. Phillips, E.A. Boudygin, B.J.
Trafton, P.A. Garris, R.M. Wightman.
Sub-second changes in accumbal dopamine during sexual behavior
in male
rats. NeuroReport, 2001,
12, 2549-2552.
1.) B.D.
Bath, D.J. Michael, B.J. Trafton,
J.D. Joseph, P.L. Runnels, R.M. Wightman.
Subsecond adsorption of dopamine at carbon-fiber microelectrodes. Analytical Chemistry, 2000, 72,
5994-6002.
Book
Chapters
M.G. Roper,
C. Guillo, and B.J. Venton. High
speed electrophoretic separations. In
“Handbook of Capillary and Microchip Electrophoresis
and Associated Microtechniques” CRC Press: New York. J.P. Landers, editor, 2008.
Invited
Lectures (from work at Virginia)
GlaxoSmithKline,
RTP, NC, Nov. 3, 2009
“The
fruit fly as a model organism for neurotransmission and pharmacology”
University
of North Carolina, Chapel Hill, NC, Nov. 2, 2009
“FSCV
at Carbon-fiber microelectrodes, moving beyond dopamine”
Indiana
University, Bloomington, IN, Oct. 1, 2009
“Electrochemical Sensors for Measuring
Neurotransmitter Changes in the Fruit Fly Brain”
University of Illinois, Chicago, Dept. of
Chemistry, Sept.
24, 2008
“Electrochemical
sensors for detection of real-time neurotransmitter changes in the
fruit fly
brain”
Mary Baldwin
College, Staunton, VA,
Sept. 18, 2008
“Using
analytical tools to study brain chemistry”
Monitoring
molecules in vivo, Vancouver, Canada,
Aug. 12, 2008
“Increasing
the sensitivity of carbon-fiber microelectrodes”
Purines
2008, Copenhagen, Denmark, July 1, 2008
“Electrochemical
detection of adenosine in vivo”
University of Virginia, Department of
Psychiatry, May 9,
2008
“Real-time
detection of neurotransmitter changes: Applications for dopamine,
serotonin,
and amino acid measurements”
Eli Lilly
& Company. Indianapolis,
IN April 15, 2008
“Electrochemical
sensors for detection of rapid neurotransmitter changes in the fruit
fly”
Pittsburgh Conference on Analytical
Chemistry,
March 3, 2008
“Carbon
nanotube modified electrodes for in vitro
and in vivo monitoring of serotonin
release”
Federation
of Analytical Chemistry and Spectroscopy Societies (FACSS), Oct. 15,
2007
“Increasing
the sensitivity of carbon-fiber microelectrodes for in vivo
applications”
Southeast
Regional Meeting of the American Chemical Society, Oct. 26, 2007
“Real-time
measurements of adenosine in vivo
using carbon-fiber mciroelectrodes”
University of Virginia, Molecular Physiology
and
Biophysics Seminar Series, Oct. 8, 2007.
“Real-time
detection of neurotransmitter changes: Applications for dopamine,
serotonin,
and adenosine measurements”
University of North Carolina, Wightman Symposium,
July 21, 2007.
“Increasing
the sensitivity of carbon fiber microelectrodes for in vivo
applications”
University of Virginia, Dept. of Anesthesiology
Seminar
Series, May 8, 2007
“Microelectrodes
for studying rapid neurochemical changes: Applications for adenosine,
dopamine
and serotonin measurements.”
University of Virginia, Neuroscience Seminar
Series, April
3, 2007
“Sensing
and sampling techniques for measuring dynamic changes of
neurotransmitters in vivo”
Pittsburgh Conference on Analytical
Chemistry,
Feb 28, 2007
“Carbon
nanotube modified microelectrodes for rapid determination of
neurochemical
changes”,
Wake Forest
University, Dept. of Chemistry,
Feb. 8, 2006
“High speed
separations for detection of fast neurochemical changes during
behavior.”
Professional
Memberships
American Chemical
Society
Society for
Neuroscience
Selected
Contributed Conference Abstracts
From
work at Virginia
M.L.
Huffman and B.J. Venton. Measurements of
adenosine efflux in rat brain slices by fast-scan cyclic voltammetry. Society for Neuroscience meeting, 2009.
T.L.
Vickrey and B.J. Venton. Measurements of
dopamine in Drosophila melanogaster
using fast-scan cyclic voltammetry. Drosophila Neurobiology Meeting, Cold Spring
Harbor, 2009.
T.L.
Vickrey, X. Borue, and B.J. Venton.
Measurements of dopamine in Drosophila
melanogaster using fast-scan cyclic voltammetry.
Pittsburgh Conference on Analytical Chemistry, 2009.
T.L.
Vickrey and B.J. Venton.
Measurements of Dopamine in Drosophila melanogaster using
Fast Scan Cyclic Voltammetry. Virginia
Academy of Sciences Meeting. 2009.
M.L.
Huffman and B.J. Venton. Measurements
of adenosine efflux in rat brain
slices by fast-scan cyclic voltammetry. Pittsburgh Conference on Analytical Chemistry, 2009.
C.B.
Jacobs, N. Hershey, H.G.
Park, and B.J. Venton. Increasing the
sensitivity of catecholamine
detection at carbon fiber microelectrodes by carbon nanotube
dip-coating. Pittsburgh
Conference on Analytical Chemistry, 2009.
X. Borue
and B.J. Venton. Rapid
detection of extracellular serotonin in
Drosophila larvae. Society for
Neuroscience Meeting. 2008.
S. Cechova
and B.J. Venton. Adenosine
A1 receptor mediate both
electrically-stimulated dopamine and adenosine concentration in rat
caudate-putamen. Society for
Neuroscience Meeting, 2008.
X. Borue
and B.J. Venton. Quantitative
evaluation of serotonin release
and reuptake in drosophila. Monitoring
molecules in Neuroscience, 2008.
S. Cechova
and B.J. Venton. Simultaneous
measurements of dopamine and
adenosine concentrations in the rat caudate-putamen.
Purines 2008.
M.L.
Huffman and B.J. Venton. Comparison
of different carbon fiber kinetics
by fast-scan cyclic voltammetry, Pittsburgh
Conference on Analytical Chemistry, 2008.
S. Cechova
and B.J. Venton. Detection
of adenosine concentration changes
with carbon microelectrodes using fast-scan cyclic voltammetry in
striatum of
anesthetized rats, Society for
Neuroscience Meeting, 2007.
X. Borue,
S.E. Cooper, B. Condron, B.J. Venton.
Rapid detection of extracellular dopamine
levels in the fruit fly, Society for
Neuroscience Meeting, 2007.
B.E. Kumara
Swamy and B.J. Venton. Rapid
monitoring of adenosine concentrations with fast-scan cyclic
voltammetry, Pittsburgh Conference on Analytical
Chemistry, 2007.
B.J.
Venton and
B.E. Kumara Swamy. Development
of a carbon-fiber microelectrode sensor for sub-second detection of
adenosine
concentrations. Society for
Neuroscience Meeting, 2006.
Work
previous to Virginia
B.M. Kile, B.J. Venton, George Augustine, R. Mark
Wightman. Evaluation of
calcium dependent dopamine
release in synapsin triple knockout mice. Society
for Neuroscience Meeting, 2007.
B.J.
Venton,
T.E. Robinson, R.T. Kennedy, S.E.
Maren. Transient changes in glutamate
and GABA release during acquisition and expression of conditioned fear. Society
for Neuroscience Meeting, 2005.
B.J.
Venton, T.E.
Robinson, R.T. Kennedy. Fast
changes in amino acid neurotransmitters are correlated with stress
behaviors: A microdialysis with online
capillary
electrophoresis study. Pittsburgh
Conference on Analytical Chemistry, 2005.
B.J.
Venton,
T.E. Robinson, R.T. Kennedy. Monitoring
fast changes in amine
neurotransmitters using microdialysis with on-line capillary
electrophoresis
detection. American Chemical
Society National Meeting, Aug. 2004 (invited).
B.J.
Venton, C.J.
Watson, A.-N. Samaha, T.E.
Robinson, R.T. Kennedy. Monitoring amine
neurotransmitters in freely-moving rats using microdialysis with
on-line
capillary electrophoresis detection. American Chemical Society Central Regional
Meeting, 2004 (invited).
B.J.
Venton,
P.E.M. Phillips, D. Gitler, W.C.
Wetsel, G.J. Augustine, R.M. Wightman.
Cocaine enhances dopamine release through mobilization of a
synapsin-sensitive pool. Society
for Neuroscience Meeting, 2003.
B.J.
Venton,
R.M. Wightman. Correlation of
extracellular oxygen and pH
changes in the rat caudate-putamen. Society
for Neuroscience Meeting, 2002.
B.J.
Venton, R.M. Wightman. Dopamine
diffusion in the brain measured by amperometry. Pittsburgh Conference on
Analytical
Chemistry, 2002.
B.J.
Trafton,
E.A. Boudygin, P.E.M. Phillips,
D.L. Robinson. The pharmacodynamics of
cocaine and GBR 12909: effect on evoked dopamine release measured by
fast scan
cyclic voltammetry in vivo. Society for
Neuroscience Meeting, 2000.
last
updated 11/10/09
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