Yan Laboratory
Molecular
Exercise Physiology

Center for Skeletal Muscle Research
Robert M. Berne Cardiovascular Research Center
University of Virginia School of Medicine
409 Lane Road, MR4 - 6041A
Charlottesville, VA 22908
Phone: 434-982-4477
Fax: 434-982-3139
E-mail: zhen.yan@virginia.edu

Welcome to the Yan Lab

Zhen Yan, Ph.D.
Professor

Molecular mechanism and health benefits of exercise


Non-communicable diseases, also known as chronic diseases, such as cardiovascular, metabolic and neurodegenerative diseases and cancer, account for more than 60% of the death in America and more than 75% of health care costs. On the other hand, it is undisputed that regular exercise has profound health benefits and is the most powerful intervention in prevention and treatment of these chronic diseases. We employ the state-of-the-art molecular and imaging technologies in a variety of animal models to elucidate the underlying molecular and signaling mechanisms of exercise training-induced adaptations and their impacts on health and disease. For more information, click Projects

To support "Exercise Research", please click here, indicating "Zhen Yan’s research".

"Live talk show"@1070 WINA; Interviews by NBC29; 1070 WINA, NBC29

Biography

Trained as a surgeon in China, Dr. Yan has been devoted to research on exercise and health. He obtained M.S. degree (1991) in Kinesiology from University of Illinois-Urbana Champaign and Ph.D. degree (1995) in Physiology and Cell Biology from University of Texas Health Science Center at Houston. He received his post-doctoral training (1999) in Molecular Cardiology at UT Southwestern Medical Center. After serving as a Lead Scientist (2000-2002) in the Alliance for Cellular Signaling led by Nobel Laureate Alfred Gilman, Dr. Yan moved to Duke University in 2002 and launched his independent research and was later involved in the establishment of Duke-NUS Graduate School Singapore (2006). Dr. Yan joined Cardiovascular Medicine and the Robert M. Berne Cardiovascular Research Center at University of Virginia in 2009. Dr. Yan is known for his in-depth, mechanistic research of the impact of exercise training on health and disease. He has authored more than 100 peer-reviewed articles and book chapters. Dr. Yan serves on the Organizing Committee for International Biochemistry of Exercise Conference (IBEC) and editorial boards for Journal of Biological Chemistry and American Journal of Physiology.

New publications

Over 100 peer-reviewed publications; h-index = 48; 12080 times referenced, 29 publications referenced over 100 times (Complete list at NCBI).

Wilson RJ, Drake JC, Cui D, Lewellen BM, Fisher CC, Zhang M, Kashatus DF, Palmer LA, Murphy MP, Yan ZMitochondrial protein S-nitrosation protects against ischemia reperfusion-induced denervation at neuromuscular junction in skeletal muscle. Free Radic Biol Med. 2018 Feb 9;117:180-190.PubMed PMID: 29432799.

Perry HM, Huang L, Wilson RJ, Bajwa A, Sesaki H, Yan Z, Rosin DL, Kashatus DF, Okusa MD. Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI. J Am Soc Nephrol. 2018 Jan;29(1):194-206. PubMed PMID: 29084809; PubMed Central PMCID: PMC5748924.

Wilson RJ, Drake JC, Cui D, Zhang M, Perry HM, Kashatus JA, Kusminski CM, Scherer PE, Kashatus DF, Okusa MD, Yan ZConditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy. Mitochondrion. 2017 Dec 20. pii: S1567-7249(17)30196-4. PubMed PMID: 29274400.

Call JA, Donet J, Martin KS, Sharma AK, Chen X, Zhang J, Cai J, Galarreta CA, Okutsu M, Du Z, Lira VA, Zhang M, Mehrad B, Annex BH, Klibanov AL, Bowler RP, Laubach VE, Peirce SM, Yan ZMuscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice. Free Radic Biol Med. 2017 Dec;113:212-223. PubMed PMID: 28982599; PubMed Central PMCID: PMC5740866.

Laker RC, Drake JC, Wilson RJ, Lira VA, Lewellen BM, Ryall KA, Fisher CC, Zhang M, Saucerman JJ, Goodyear LJ, Kundu M, Yan ZAmpk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy. Nat Commun. 2017 Sep 15;8(1):548. PubMed PMID: 28916822; PubMed Central PMCID: PMC5601463.

Yan Z, Kronemberger A, Blomme J, Call JA, Caster HM, Pereira RO, Zhao H, de Melo VU, Laker RC, Zhang M, Lira VA. Exercise leads to unfavourable cardiac remodelling and enhanced metabolic homeostasis in obese mice with cardiac and skeletal muscle autophagy deficiency. Sci Rep. 2017 Aug 11;7(1):7894. PubMed PMID: 28801668; PubMed Central PMCID: PMC5554260.

Call JA, Wilson RJ, Laker RC, Zhang M, Kundu M, Yan ZUlk1-mediated autophagy plays an essential role in mitochondrial remodeling and functional regeneration of skeletal muscle. Am J Physiol Cell Physiol. 2017 Jun 1;312(6):C724-C732. PubMed PMID: 28356270; PubMed Central PMCID: PMC5494591.


Associated Sites at UVa

Robert M. Berne Cardiovascular Research Center (aka CVRC)
Department of Cardiovascular Medicine
Cardiovascular Training Grant (CVTG and Facebook)

Our pMitoTimer deposited at Addgene received 292 requests!!

News

Mar. 6, 2018--Congratulations to Dr. Becky Wilson for receiving 2018 Biochemistry and Molecular Genetics Outstanding Graduate Student award! Good luck with her competition for the Peach and Hungerford awards!

Feb. 2, 2018--Congratulations to Dr. Becky Wilson for her thesis work being accepted by Free Radical Biology and Medicine. The way to go!!!

Feb. 1, 2018--Congratulations to Dr. Josh Drake for receing an impact score of 14 for an NIH K99/R00 application.

Dec. 21, 2017--Congratulations to Becky Wilson and Josh Drake for their paper on MitoTimer mice being accepted by Mitochondrion.

Nov. 15, 2017--Dr. Yan provided a training session on specific aim writing to junior faculty at UVA.

Oct. 31-Nov. 3, 2017--Dr. Yan gave a series of lectures at Tianjin University of Sport.

Oct. 25, 2017--Dr. Yan gives Taft Diabetes and ECDOI Seminar at East Carolina University in Greenville, NC.

Oct. 25, 2017--Our findings are featured by UVAToday and NBC29.

Oct. 5, 2017--Congratulations to Dr. Drake for receiving the best oral presentation award at UVA Pharmacology Annual Retreat.

Sept. 28, 2017--Drs. Call and Donet got their paper "Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice" accepted by Free Radical Biology and Medicine.

Sept. 28, 2017--Dr. Yan gave a talk entitled: "Voluntary running prevents the onset of symptomatic Friedreich's ataxia in mice" at 2017 International Ataxia Research Conference in Pisa, Italy, and was interviewed exlusively by Friedreich's Ataxia News.

Sept. 21, 2017--Yan Lab is featured by UVAToday and Medical News Today.

Sept. 18, 2017--Dr. Yan speaks at his Ala Mara, Department of Integrative Biology and Pharmacology at Univeristy of Texas Health Science Center at Houston

Sept. 15, 2017--Congratulations to Drs. Laker and Drake and the Lab for the brand new paper entitled: "AMPK phosphorylation of Ulk1 is required for lysosome targeting of mitochondria in exercise-induced mitophagy" in Nat Commun!!

Jul. 11, 2017---"Exercise leads to unfavourable cardiac remodelling and enhanced metabolic homeostasis in obese mice with cardiac and skeletal muscle autophagy deficiency" by Dr. Lira is accepted by Sci Rept. Congratualtions to Dr. Lira and co-authors! Also congratulations to Dr. Yan for his 100th peer-reviewed publications (which is 100th pending the publication date for these two recent paper)!

Jul. 5, 2017---"AMPK phosphorylation of Ulk1 is required for lysosome targeting of mitochondria in exercise-induced mitophagy" by Drs. Laker and Drake (equal constribution) is accepted by Nat Commun. Congratulations to Drs. Laker and Drake and co-authors!

Jul. 1, 2017---Dr. Yan is promoted to Professor of Medicine, Pharmacology, Molecular Physiology & Biological Physics, and Distinguished Visiting Professor of Tianjin University of Sport.

Mar. 27, 2017---The Yan Lab received new funding from UVA-AZ Research Alliance on "Small molecule screen in MitoTimer flies and mice for diabetic cardiomyopathy".

Mar. 18, 2017---Dr. Yan chaired the "Healthspan" session at Boao Forum of Biological Sciences in China

Mar. 17, 2017---A new manuscript from the Yan Lab accepted by American Journal of Physiology:Cell Physiology on mitophagy for functional muscle regeneration (First author Dr. Jarrod Call).

Feb. 22, 2017---Dr. Yan gave a Formal Research Seminar entitled:"Exercise-induced mitophagy in skeletal muscle adaptation" at Buck Institute

Feb. 22, 2017---The Yan Lab received new funding from UVA Cancer Center and Public Health (CCPH) for "Combined Endurance and Resistance Exercise on Ovarian Cancer Prevention in Mice"

Jan. 1, 2017---The Yan Lab received new funding from FARA for his research on "Endurance and resistance exercise mitigates Friedreich's ataxia".