Dr. Geng is a Post-doctoral Fellow with a Ph.D. degree in Poultry Genetics and Genomics from Virginia Polytechnic Institute and State University. His long-term research goal is to improve understanding of muscle-related human health and diseases. His current research interest focuses on exercise-induced muscle adaptation, cachexia-induced muscle atrophy and lipid overload-induced muscle insulin resistance in mouse models. His past and present topics in the Yan Laboratory are listed below:

1) To determine if PGC-1α is required for exercise-induced muscle adaptation (finished). 2) To determine if PGC-1α renders skeletal muscle resistant to cardiac cachexia
3) To determine if mitochondrial permeability transition (MPT) is essential to lipid overload-induced muscle insulin resistance
4) To determine if p38 MAPK is essential to activations of the ubiquitin-proteasomal and lysosomal/autophagic pathways in muscle atrophy

Tuoyu (Leo) Geng, Ph.D.
Post-doctoral Fellow

Phone: (434)982-4473, Fax: (434)982-3139, e-mail: leo.geng@virginia.edu
1. Guan X., P. Silva, K. B. Gyenai, J. Xu, T. Geng, Z. Tu, D. C. Samuels, and E. J. Smith (2008) The Mitochondrial Genome Sequence and Molecular Phylogeny of the Turkey, Meleagris gallopavo. Animal Genetics. Epub ahead of print. 2. Guan X., T. Geng, P. Silva, and E. J. Smith. (2007) Mitochondrial DNA Sequence and Haplotype Variation Analysis in the Chicken (Gallus gallus). Journal of Heredity. 98:723-726
3. Kamara, D.F., T. Geng, S. Guynn, K. Hopwood, & E. J. Smith, (2007) Isolation and characterization of microsatellite markers from the budgerigar, Melopsittacus undulates. Molecular Ecology Notes. 7: 507–509.
4. Lin, K.C., J. Xu, D. F. Kamara, T. Geng, K.B. Gyenai, K.M. Reed, & E. J. Smith. (2007) DNA sequence and haplotype variation in two candidate genes for dilated cardiomyopathy in the turkey, Meleagris gallopavo. Genome. 50: 463-469.
5. Kamara D. F., K. B. Gyenai, T. Geng, and E. J. Smith. (2007) Microsatellite Microsatellite Marker-Based Genetic Analysis of Relatedness Between Commercial and Heritage Turkeys (Meleagris gallopavo). Poultry Science. 85: 46-49. 6. Lin K.C., K. B. Gyenai, R. L. Pyle, T. Geng, J. Xu, and E. J. Smith. (2006) Candidate Gene Expression Analysis of Toxin-Induced Dilated Cardiomyopathy in the Turkey (Meleagris gallopavo). Poultry Science. 85: 2216-2221.
7. Hartman S., S. A. Taleb, T. Geng, X. Guan, K. Gyenai, and E J. Smith (2006) Comparison of Plasma Uric Acid Levels in Five Varieties of the Domestic Turkey, Meleagris gallopavo. Poultry Science. 85: 1791-1794.
8. Smith E. J., T. Geng, E. C. Long, F. Pierson, D. Sponenberg, C. Larson, R. Gogal (2005) Molecular Analysis of the Relatedness of Five Domesticated Turkey Strains. Biochemical Genetics. 43:35-47.
9. Smith E. J., D.F. Kamara, G. Pimentel, T. Geng, X. Guan, K.-C., Lin and S. Hartman. (2005) Avian Genomics: Important Resources for Understanding Vertebrate Biology. Current Genomics. 6:75-80.
10. Hartman, S., G. Touchton, J. Wynn, T. Geng, N. W. Chong, and E. J. Smith (2005) Characterization of Expressed Sequence Tags from a Gallus gallus Pineal Gland cDNA Library. Comparative and Functional Genomics. 6:301-306.