Publications

110 peer-reviewed publications; h-index = 52; 15009 times referenced (Google Scholar), 31 publications referenced over 100 times (Complete list at NCBI).

Peer-reviewed articles 
110. Guan Y, Drake JC, Yan ZExercise-Induced Mitophagy in Skeletal Muscle and Heart. Exerc Sport Sci Rev. 2019 Apr 11. doi: 10.1249/JES.0000000000000192. [Epub ahead of print] PubMed PMID: 30985475.

109. Wilson RJ, Drake JC, Cui D, Zhang M, Perry HM, Kashatus JA, Kusminski CM, Scherer PE, Kashatus DF, Okusa MD, Yan ZConditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy. Mitochondrion. 2019 Jan;44:20-26. doi: 10.1016/j.mito.2017.12.008. Epub 2017 Dec 20. PubMed PMID: 29274400. (Full text PDF)

108. Xu P, Damschroder D, Zhang M, Ryall KA, Adler PN, Saucerman JJ, Wessells RJ, Yan ZAtg2, Atg9 and Atg18 in mitochondrial integrity, cardiac function and healthspan in Drosophila. J Mol Cell Cardiol. 2018 Dec 17;127:116-124. doi: 10.1016/j.yjmcc.2018.12.006. [Epub ahead of print] PubMed PMID: 30571977. (Full text PDF)

107. Drake JC, Laker RC, Wilson RJ, Zhang M, Yan ZExercise-induced mitophagy in skeletal muscle occurs in the absence of stabilization of Pink1 on mitochondria. Cell Cycle. 2018 Dec 17. doi: 10.1080/15384101.2018.1559556. [Epub ahead of print] PubMed PMID: 30558471. (Full text PDF)

106. Wilson RJ, Drake JC, Cui D, Ritger ML, Guan Y, Call JA, Zhang M, Leitner LM, Gödecke A, Yan ZVoluntary running protects against neuromuscular dysfunction following hindlimb ischemia-reperfusion in mice. J Appl Physiol (1985). 2018 Nov 15. doi: 10.1152/japplphysiol.00358.2018. [Epub ahead of print] PubMed PMID: 30433863. (Full text PDF)

105. Wilson RJ, Drake JC, Cui D, Lewellen BM, Fisher CC, Zhang M, Kashatus DF, Palmer LA, Murphy MP, Yan ZMitochondrial protein S-nitrosation protects against ischemia reperfusion-induced denervation at neuromuscular junction in skeletal muscle. Free Radic Biol Med. 2018 Mar;117:180-190. doi: 10.1016/j.freeradbiomed.2018.02.006. Epub 2018 Feb 9. PubMed PMID: 29432799; PubMed Central PMCID: PMC5896769. (Full text PDF)

104. Perry HM, Huang L, Wilson RJ, Bajwa A, Sesaki H, Yan Z, Rosin DL, Kashatus DF, Okusa MD. Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI. J Am Soc Nephrol. 2018 Jan;29(1):194-206. doi: 10.1681/ASN.2017060659. Epub 2017 Oct 30. PubMed PMID: 29084809; PubMed Central PMCID: PMC5748924. (Full text PDF)

103. Call JA, Donet J, Martin KS, Sharma AK, Chen X, Zhang J, Cai J, Galarreta CA, Okutsu M, Du Z, Lira VA, Zhang M, Mehrad B, Annex BH, Klibanov AL, Bowler RP, Laubach VE, Peirce SM, Yan ZMuscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice. Free Radic Biol Med. 2017 Dec;113:212-223. doi: 10.1016/j.freeradbiomed.2017.09.029. Epub 2017 Oct 2. PubMed PMID: 28982599; PubMed Central PMCID: PMC5740866.

102. Keller AS, Diederich L, Panknin C, DeLalio LJ, Drake JC, Sherman R, Jackson EK, Yan Z, Kelm M, Cortese-Krott MM, Isakson BE. Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway. Am J Physiol Cell Physiol. 2017 Dec 1;313(6):C593-C603. doi: 10.1152/ajpcell.00178.2017. Epub 2017 Aug 30. PubMed PMID: 28855161; PubMed Central PMCID: PMC5814586.

101. Drake JC, Yan ZMitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with ageing. J Physiol. 2017 Oct 15;595(20):6391-6399. doi: 10.1113/JP274337. Epub 2017 Sep 24. Review. PubMed PMID: 28795394; PubMed Central PMCID: PMC5638883.

100. Laker RC, Drake JC, Wilson RJ, Lira VA, Lewellen BM, Ryall KA, Fisher CC, Zhang M, Saucerman JJ, Goodyear LJ, Kundu M, Yan ZAmpk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy. Nat Commun. 2017 Sep 15;8(1):548. doi: 10.1038/s41467-017-00520-9. PubMed PMID: 28916822; PubMed Central PMCID: PMC5601463.

99. Yan Z, Kronemberger A, Blomme J, Call JA, Caster HM, Pereira RO, Zhao H, de Melo VU, Laker RC, Zhang M, Lira VA. Exercise leads to unfavourable cardiac remodelling and enhanced metabolic homeostasis in obese mice with cardiac and skeletal muscle autophagy deficiency. Sci Rep. 2017 Aug 11;7(1):7894. doi: 10.1038/s41598-017-08480-2. PubMed PMID: 28801668; PubMed Central PMCID: PMC5554260.

98. Call JA, Wilson RJ, Laker RC, Zhang M, Kundu M, Yan ZUlk1-mediated autophagy plays an essential role in mitochondrial remodeling and functional regeneration of skeletal muscle. Am J Physiol Cell Physiol. 2017 Jun 1;312(6):C724-C732. doi: 10.1152/ajpcell.00348.2016. Epub 2017 Mar 29. PubMed PMID: 28356270; PubMed Central PMCID: PMC5494591.

97. Leitner LM, Wilson RJ, Yan Z, Gödecke A. Reactive Oxygen Species/Nitric Oxide Mediated Inter-Organ Communication in Skeletal Muscle Wasting Diseases. Antioxid Redox Signal. 2017 May 1;26(13):700-717. doi: 10.1089/ars.2016.6942. Epub 2017 Jan 4. Review. PubMed PMID: 27835923; PubMed Central PMCID: PMC5421600.

96. Taddeo EP, Hargett SR, Lahiri S, Nelson ME, Liao JA, Li C, Slack-Davis JK, Tomsig JL, Lynch KR, Yan Z, Harris TE, Hoehn KL. Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3. Sci Rep. 2017 Mar 9;7(1):127. doi: 10.1038/s41598-017-00210-y. PubMed PMID: 28273928; PubMed Central PMCID: PMC5428006.

95. Forrester SJ, Elliott KJ, Kawai T, Obama T, Boyer MJ, Preston KJ, Yan Z, Eguchi S, Rizzo V. Caveolin-1 Deletion Prevents Hypertensive Vascular Remodeling Induced by Angiotensin II. Hypertension. 2017 Jan;69(1):79-86. Epub 2016 Nov 28. PubMed PMID: 27895190; PubMed Central PMCID: PMC5145768.

94. Laker RC, Taddeo EP, Akhtar YN, Zhang M, Hoehn KL, Yan ZThe Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis. PLoS One. 2016 Dec 22;11(12):e0167910. doi: 10.1371/journal.pone.0167910. eCollection 2016. PubMed PMID: 28005946; PubMed Central PMCID: PMC5179060.

93. Klionsky DJ,…Yan Z,…Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. PubMed PMID: 26799652; PubMed Central PMCID: PMC4835977.

92. Drake JC, Wilson RJ, Yan ZMolecular mechanisms for mitochondrial adaptation to exercise training in skeletal muscle. FASEB J. 2016 Jan;30(1):13-22. doi: 10.1096/fj.15-276337. Epub 2015 Sep 14. Review. PubMed PMID: 26370848; PubMed Central PMCID: PMC6137621.

91. Booth FW, Ruegsegger GN, Toedebusch RG, Yan ZEndurance Exercise and the Regulation of Skeletal Muscle Metabolism. Prog Mol Biol Transl Sci. 2015;135:129-51. doi: 10.1016/bs.pmbts.2015.07.016. Epub 2015 Sep 5. Review. PubMed PMID: 26477913.

90. Chao H, Li H, Grande R, Lira V, Yan Z, Harris TE, Li C. Involvement of mTOR in Type 2 CRF Receptor Inhibition of Insulin Signaling in Muscle Cells. Mol Endocrinol. 2015 Jun;29(6):831-41. doi: 10.1210/me.2014-1245. Epub 2015 Apr 15. PubMed PMID: 25875045; PubMed Central PMCID: PMC4447643.

89. Cohen TJ, Choi MC, Kapur M, Lira VA, Yan Z, Yao TP. HDAC4 regulates muscle fiber type-specific gene expression programs. Mol Cells. 2015 Apr;38(4):343-8. doi: 10.14348/molcells.2015.2278. Epub 2015 Feb 25. PubMed PMID: 25728750; PubMed Central PMCID: PMC4400309.

88. Call JA, Chain KH, Martin KS, Lira VA, Okutsu M, Zhang M, Yan ZEnhanced skeletal muscle expression of extracellular superoxide dismutase mitigates streptozotocin-induced diabetic cardiomyopathy by reducing oxidative stress and aberrant cell signaling. Circ Heart Fail. 2015 Jan;8(1):188-97. doi: 10.1161/CIRCHEARTFAILURE.114.001540. Epub 2014 Dec 11. PubMed PMID: 25504759; PubMed Central PMCID: PMC4445759.

87. Lee HY, Gattu AK, Camporez JP, Kanda S, Guigni B, Kahn M, Zhang D, Galbo T, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Choi CS, Yan Z, Williams RS, Shulman GI, Samuel VT. Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia. 2014 Jun;57(6):1232-41. doi: 10.1007/s00125-014-3212-1. Epub 2014 Apr 11. PubMed PMID: 24718953; PubMed Central PMCID: PMC5634138.

86. Laker RC, Connelly JJ, Yan ZResponse to comment on Laker et al. Exercise prevents maternal high-fat diet-induced hypermethylation of the pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes 2014;63:1605-1611.Diabetes. 2014 May;63(5):e6-7. doi: 10.2337/db14-0135. PubMed PMID: 24757208; PubMed Central PMCID: PMC5860828.

85. Okutsu M, Call JA, Lira VA, Zhang M, Donet JA, French BA, Martin KS, Peirce-Cottler SM, Rembold CM, Annex BH, Yan ZExtracellular superoxide dismutase ameliorates skeletal muscle abnormalities, cachexia, and exercise intolerance in mice with congestive heart failure. Circ Heart Fail. 2014 May;7(3):519-30. doi: 10.1161/CIRCHEARTFAILURE.113.000841. Epub 2014 Feb 12. PubMed PMID: 24523418; PubMed Central PMCID: PMC4080303.

84. Laker RC, Lillard TS, Okutsu M, Zhang M, Hoehn KL, Connelly JJ, Yan ZExercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes. 2014 May;63(5):1605-11. doi: 10.2337/db13-1614. Epub 2014 Jan 15. PubMed PMID: 24430439; PubMed Central PMCID: PMC5860829.

83. Laker RC, Xu P, Ryall KA, Sujkowski A, Kenwood BM, Chain KH, Zhang M, Royal MA, Hoehn KL, Driscoll M, Adler PN, Wessells RJ, Saucerman JJ, Yan ZA novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo. J Biol Chem. 2014 Apr 25;289(17):12005-15. doi: 10.1074/jbc.M113.530527. Epub 2014 Mar 18. PubMed PMID: 24644293; PubMed Central PMCID: PMC4002107.

82. Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab. 2013 Nov 28;3(2):114-23. doi: 10.1016/j.molmet.2013.11.005. eCollection 2014 Apr. PubMed PMID: 24634817; PubMed Central PMCID: PMC3953706.

81. Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Harris TE, Keller SR, Chow JD, Lynch KR, Chokki M, Molkentin JD, Turner N, James DE, Yan Z, Hoehn KL. Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Mol Metab. 2013 Nov 26;3(2):124-34. doi: 10.1016/j.molmet.2013.11.003. eCollection 2014 Apr. PubMed PMID: 24634818; PubMed Central PMCID: PMC3953683.

80. Hindi SM, Mishra V, Bhatnagar S, Tajrishi MM, Ogura Y, Yan Z, Burkly LC, Zheng TS, Kumar A. Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program. FASEB J. 2014 Mar;28(3):1398-411. doi: 10.1096/fj.13-242123. Epub 2013 Dec 10. PubMed PMID: 24327607; PubMed Central PMCID: PMC3929677.

79. Lira VA, Okutsu M, Zhang M, Greene NP, Laker RC, Breen DS, Hoehn KL, Yan ZAutophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. FASEB J. 2013 Oct;27(10):4184-93. doi: 10.1096/fj.13-228486. Epub 2013 Jun 27. PubMed PMID: 23825228; PubMed Central PMCID: PMC4046188. 

78. Katwal AB, Konkalmatt PR, Piras BA, Hazarika S, Li SS, John Lye R, Sanders JM, Ferrante EA, Yan Z, Annex BH, French BA. Adeno-associated virus serotype 9 efficiently targets ischemic skeletal muscle following systemic delivery. Gene Ther. 2013 Sep;20(9):930-8. doi: 10.1038/gt.2013.16. Epub 2013 Mar 28. PubMed PMID: 23535898; PubMed Central PMCID: PMC3758463.

77. Zhang C, He Y, Okutsu M, Ong LC, Jin Y, Zheng L, Chow P, Yu S, Zhang M, Yan ZAutophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation. Am J Physiol Endocrinol Metab. 2013 Aug 15;305(4):E530-9. doi: 10.1152/ajpendo.00640.2012. Epub 2013 Jun 25. PubMed PMID: 23800883; PubMed Central PMCID: PMC5504416.

76. Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P, Arany Z. Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle. Cell Rep. 2013 May 30;3(5):1449-56. doi: 10.1016/j.celrep.2013.04.023. Epub 2013 May 23. PubMed PMID: 23707060; PubMed Central PMCID: PMC3688451.

75. Hochreiter-Hufford AE, Lee CS, Kinchen JM, Sokolowski JD, Arandjelovic S, Call JA, Klibanov AL, Yan Z, Mandell JW, Ravichandran KS. Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature. 2013 May 9;497(7448):263-7. doi: 10.1038/nature12135. Epub 2013 Apr 24. PubMed PMID: 23615608; PubMed Central PMCID: PMC3773542.

74. Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Jung DY, Okutsu M, Yan Z, Kim JK, Lin JD. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nat Med. 2013 May;19(5):640-5. doi: 10.1038/nm.3144. Epub 2013 Apr 7. PubMed PMID: 23563706; PubMed Central PMCID: PMC3650110.

73. Laker RC, Wlodek ME, Connelly JJ, Yan Z. Epigenetic origins of metabolic disease: The impact of the maternal condition to the offspring epigenome and later health consequences. Food Science and Human Wellness . 2013; 2(1):1-11.

72. Zhang C, Li S, Yang L, Huang P, Li W, Wang S, Zhao G, Zhang M, Pang X, Yan Z, Liu Y, Zhao L. Structural modulation of gut microbiota in life-long calorie-restricted mice. Nat Commun. 2013;4:2163. doi: 10.1038/ncomms3163. PubMed PMID: 23860099; PubMed Central PMCID: PMC3717500.

71. Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM. A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell. 2012 Dec 7;151(6):1319-31. doi: 10.1016/j.cell.2012.10.050. PubMed PMID: 23217713; PubMed Central PMCID: PMC3520615.

70. Gagan J, Dey BK, Layer R, Yan Z, Dutta A. Notch3 and Mef2c proteins are mutually antagonistic via Mkp1 protein and miR-1/206 microRNAs in differentiating myoblasts. J Biol Chem. 2012 Nov 23;287(48):40360-70. doi: 10.1074/jbc.M112.378414. Epub 2012 Oct 10. PubMed PMID: 23055528; PubMed Central PMCID: PMC3504751.

69. Dey BK, Gagan J, Yan Z, Dutta A. miR-26a is required for skeletal muscle differentiation and regeneration in mice. Genes Dev. 2012 Oct 1;26(19):2180-91. doi: 10.1101/gad.198085.112. PubMed PMID: 23028144; PubMed Central PMCID: PMC3465739.

68. Baltgalvis KA, Call JA, Cochrane GD, Laker RC, Yan Z, Lowe DA. Exercise training improves plantar flexor muscle function in mdx mice. Med Sci Sports Exerc. 2012 Sep;44(9):1671-9. PubMed PMID: 22460476; PubMed Central PMCID: PMC3470762.

67. Yan Z, Lira VA, Greene NP. Exercise training-induced regulation of mitochondrial quality. Exerc Sport Sci Rev. 2012 Jul;40(3):159-64. doi: 10.1097/JES.0b013e3182575599. Review. PubMed PMID: 22732425; PubMed Central PMCID: PMC3384482.

66. Zhou B, Yang L, Li S, Huang J, Chen H, Hou L, Wang J, Green CD, Yan Z, Huang X, Kaeberlein M, Zhu L, Xiao H, Liu Y, Han JD. Midlife gene expressions identify modulators of aging through dietary interventions. Proc Natl Acad Sci U S A. 2012 May 8;109(19):E1201-9. doi: 10.1073/pnas.1119304109. Epub 2012 Apr 16. PubMed PMID: 22509016; PubMed Central PMCID: PMC3358859.

65. Meher AK, Sharma PR, Lira VA, Yamamoto M, Kensler TW, Yan Z, Leitinger N. Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance. Free Radic Biol Med. 2012 May 1;52(9):1708-15. doi: 10.1016/j.freeradbiomed.2012.02.022. Epub 2012 Feb 24. PubMed PMID: 22370093; PubMed Central PMCID: PMC3383807.

64. Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6739-44. doi: 10.1073/pnas.1121060109. Epub 2012 Apr 9. PubMed PMID: 22493257; PubMed Central PMCID: PMC3340075.

63. Griffin TM, Huebner JL, Kraus VB, Yan Z, Guilak F. Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise. Arthritis Rheum. 2012 Feb;64(2):443-53. doi: 10.1002/art.33332. PubMed PMID: 21953366; PubMed Central PMCID: PMC3268860.

62. Wada S, Kato Y, Okutsu M, Miyaki S, Suzuki K, Yan Z, Schiaffino S, Asahara H, Ushida T, Akimoto T. Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy. J Biol Chem. 2011 Nov 4;286(44):38456-65. doi: 10.1074/jbc.M111.271270. Epub 2011 Sep 18. PubMed PMID: 21926429; PubMed Central PMCID: PMC3207415.

61. Gagan J, Dey BK, Layer R, Yan Z, Dutta A. MicroRNA-378 targets the myogenic repressor MyoR during myoblast differentiation. J Biol Chem. 2011 Jun 3;286(22):19431-8. doi: 10.1074/jbc.M111.219006. Epub 2011 Apr 6. PubMed PMID: 21471220; PubMed Central PMCID: PMC3103322.

60. Geng T, Li P, Yin X, Yan ZPGC-1α promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice. Am J Pathol. 2011 Apr;178(4):1738-48. doi: 10.1016/j.ajpath.2011.01.005. PubMed PMID: 21435455; PubMed Central PMCID: PMC3078433.

59. Yan Z, Okutsu M, Akhtar YN, Lira VA. Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol (1985). 2011 Jan;110(1):264-74. doi: 10.1152/japplphysiol.00993.2010. Epub 2010 Oct 28. Review. PubMed PMID: 21030673; PubMed Central PMCID: PMC3253006.

58. Zechner C, Lai L, Zechner JF, Geng T, Yan Z, Rumsey JW, Collia D, Chen Z, Wozniak DF, Leone TC, Kelly DP. Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. Cell Metab. 2010 Dec 1;12(6):633-42. doi: 10.1016/j.cmet.2010.11.008. Erratum in: Cell Metab. 2011 Jan 5;13(1):114. PubMed PMID: 21109195; PubMed Central PMCID: PMC2999961.

57. Chen JF, Tao Y, Li J, Deng Z, Yan Z, Xiao X, Wang DZ. microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. J Cell Biol. 2010 Sep 6;190(5):867-79. doi: 10.1083/jcb.200911036. PubMed PMID: 20819939; PubMed Central PMCID: PMC2935565.

56. Lira VA, Benton CR, Yan Z, Bonen A. PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E145-61. doi: 10.1152/ajpendo.00755.2009. Epub 2010 Apr 6. Review. PubMed PMID: 20371735; PubMed Central PMCID: PMC2928513. Full text (PDF)

55. Huang P, Li S, Shao M, Qi Q, Zhao F, You J, Mao T, Li W, Yan Z, Liu Y. Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice. Nutr Metab (Lond). 2010 Jul 16;7:59. doi: 10.1186/1743-7075-7-59. PubMed PMID: 20633301; PubMed Central PMCID: PMC2914080.

54. Geng T, Li P, Okutsu M, Yin X, Kwek J, Zhang M, Yan ZPGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. Am J Physiol Cell Physiol. 2010 Mar;298(3):C572-9. doi: 10.1152/ajpcell.00481.2009. Epub 2009 Dec 23. PubMed PMID: 20032509; PubMed Central PMCID: PMC3353735.

53. McClung JM, Judge AR, Powers SK, Yan Zp38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting. Am J Physiol Cell Physiol. 2010 Mar;298(3):C542-9. doi: 10.1152/ajpcell.00192.2009. Epub 2009 Dec 2. PubMed PMID: 19955483; PubMed Central PMCID: PMC2838571.

52. Pogozelski AR, Geng T, Li P, Yin X, Lira VA, Zhang M, Chi JT, Yan Zp38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice. PLoS One. 2009 Nov 20;4(11):e7934. doi: 10.1371/journal.pone.0007934. PubMed PMID: 19936205; PubMed Central PMCID: PMC2775956. Full text (PDF)

51. Yan ZExercise, PGC-1alpha, and metabolic adaptation in skeletal muscle. Appl Physiol Nutr Metab. 2009 Jun;34(3):424-7. doi: 10.1139/H09-030. Review. PubMed PMID: 19448709; PubMed Central PMCID: PMC3354917. Full text (PDF) 

50. Ajijola OA, Dong C, Herderick EE, Ma Q, Goldschmidt-Clermont PJ, Yan ZVoluntary running suppresses proinflammatory cytokines and bone marrow endothelial progenitor cell levels in apolipoprotein-E-deficient mice. Antioxid Redox Signal. 2009 Jan;11(1):15-23. doi: 10.1089/ars.2008.2092. PubMed PMID: 18837653; PubMed Central PMCID: PMC2933158. Full text (PDF) 

49. Hazarika S, Angelo M, Li Y, Aldrich AJ, Odronic SI, Yan Z, Stamler JS, Annex BH. Myocyte specific overexpression of myoglobin impairs angiogenesis after hind-limb ischemia. Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2144-50. doi: 10.1161/ATVBAHA.108.170951. Epub 2008 Sep 25. PubMed PMID: 18818418; PubMed Central PMCID: PMC3152376. Full text (PDF) 

48. Sun B, Young SP, Li P, Di C, Brown T, Salva MZ, Li S, Bird A, Yan Z, Auten R, Hauschka SD, Koeberl DD. Correction of multiple striated muscles in murine Pompe disease through adeno-associated virus-mediated gene therapy. Mol Ther. 2008 Aug;16(8):1366-71. doi: 10.1038/mt.2008.133. Epub 2008 Jun 17. PubMed PMID: 18560415; PubMed Central PMCID: PMC2670546. Full text (PDF) 

47. Akimoto T, Li P, Yan ZFunctional interaction of regulatory factors with the Pgc-1alpha promoter in response to exercise by in vivo imaging. Am J Physiol Cell Physiol. 2008 Jul;295(1):C288-92. doi: 10.1152/ajpcell.00104.2008. Epub 2008 Apr 23. PubMed PMID: 18434626; PubMed Central PMCID: PMC2493547. Full text (PDF)

46. Davis AJ, Yan Z, Martinez B, Mumby MC. Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit. J Biol Chem. 2008 Jun 6;283(23):16104-14. doi: 10.1074/jbc.M710313200. Epub 2008 Apr 8. PubMed PMID: 18397887; PubMed Central PMCID: PMC2414307. Full text (PDF) 

45. Yu Z, Li P, Zhang M, Hannink M, Stamler JS, Yan ZFiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli. PLoS One. 2008 May 7;3(5):e2086. doi: 10.1371/journal.pone.0002086. PubMed PMID: 18461174; PubMed Central PMCID: PMC2361191. Full text (PDF) 

44. Wooldridge AA, Fortner CN, Lontay B, Akimoto T, Neppl RL, Facemire C, Datto MB, Kwon A, McCook E, Li P, Wang S, Thresher RJ, Miller SE, Perriard JC, Gavin TP, Hickner RC, Coffman TM, Somlyo AV, Yan Z, Haystead TA. Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. J Biol Chem. 2008 Apr 25;283(17):11850-9. doi: 10.1074/jbc.M708628200. Epub 2008 Feb 29. PubMed PMID: 18310078; PubMed Central PMCID: PMC2431077. Full text (PDF)

43. Handschin C, Chin S, Li P, Liu F, Maratos-Flier E, Lebrasseur NK, Yan Z, Spiegelman BM. Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem. 2007 Oct 12;282(41):30014-21. Epub 2007 Aug 16. PubMed PMID: 17702743. Full text (PDF) 

42. Jeftinija DM, Wang QB, Hebert SL, Norris CM, Yan Z, Rich MM, Kraner SD. The Ca(V) 1.2 Ca(2+) channel is expressed in sarcolemma of type I and IIa myofibers of adult skeletal muscle. Muscle Nerve. 2007 Oct;36(4):482-90. PubMed PMID: 17636479; PubMed Central PMCID: PMC2756106. Full text (PDF)

41. Yan Z, Li P, Akimoto T. Transcriptional control of the Pgc-1alpha gene in skeletal muscle in vivo. Exerc Sport Sci Rev. 2007 Jul;35(3):97-101. Review. PubMed PMID: 17620927.

40. Li P, Waters RE, Redfern SI, Zhang M, Mao L, Annex BH, Yan ZOxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice. Am J Pathol. 2007 Feb;170(2):599-608. PubMed PMID: 17255328; PubMed Central PMCID: PMC1851852. Full text (PDF)

39. Perrino C, Naga Prasad SV, Mao L, Noma T, Yan Z, Kim HS, Smithies O, Rockman HA. Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. J Clin Invest. 2006 Jun;116(6):1547-60. PubMed PMID: 16741575; PubMed Central PMCID: PMC1464895. Full text (PDF)

38. Li P, Akimoto T, Zhang M, Williams RS, Yan ZResident stem cells are not required for exercise-induced fiber-type switching and angiogenesis but are necessary for activity-dependent muscle growth. Am J Physiol Cell Physiol. 2006 Jun;290(6):C1461-8. Epub 2006 Jan 11. PubMed PMID: 16407413. Full text (PDF)

37. Yan Z, Williams RS. Principles of Molecular Medicine . 2nd ed. Marschall SR, Patterson C, editors. Totowa, NJ: Humana Press; 2006. Skeletal muscle hypertrophy and response to training. 688-92p. 

36. Choi S, Liu X, Li P, Akimoto T, Lee SY, Zhang M, Yan ZTranscriptional profiling in mouse skeletal muscle following a single bout of voluntary running: evidence of increased cell proliferation. J Appl Physiol (1985). 2005 Dec;99(6):2406-15. Epub 2005 Aug 4. PubMed PMID: 16081620. Full text (PDF)

35. Koves TR, Li P, An J, Akimoto T, Slentz D, Ilkayeva O, Dohm GL, Yan Z, Newgard CB, Muoio DM. Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem. 2005 Sep 30;280(39):33588-98. Epub 2005 Aug 3. PubMed PMID: 16079133. Full text (PDF)

34. Akimoto T, Pohnert SC, Li P, Zhang M, Gumbs C, Rosenberg PB, Williams RS, Yan ZExercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. J Biol Chem. 2005 May 20;280(20):19587-93. Epub 2005 Mar 14. PubMed PMID: 15767263. Full text (PDF)

33. Akimoto T, Ushida T, Miyaki S, Akaogi H, Tsuchiya K, Yan Z, Williams RS, Tateishi T. Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling. Biochem Biophys Res Commun. 2005 Apr 1;329(1):381-5. PubMed PMID: 15721317.

32. Zhu X, Hart R, Chang MS, Kim JW, Lee SY, Cao YA, Mock D, Ke E, Saunders B, Alexander A, Grossoehme J, Lin KM, Yan Z, Hsueh R, Lee J, Scheuermann RH, Fruman DA, Seaman W, Subramaniam S, Sternweis P, Simon MI, Choi S. Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands. J Immunol. 2004 Dec 15;173(12):7141-9. PubMed PMID: 15585835. Full text (PDF)

31. Waters RE, Rotevatn S, Li P, Annex BH, Yan ZVoluntary running induces fiber type-specific angiogenesis in mouse skeletal muscle. Am J Physiol Cell Physiol. 2004 Nov;287(5):C1342-8. Epub 2004 Jul 14. PubMed PMID: 15253894. Full text (PDF)

30. Akimoto T, Ribar TJ, Williams RS, Yan ZSkeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV-deficient mice. Am J Physiol Cell Physiol. 2004 Nov;287(5):C1311-9. Epub 2004 Jun 30. PubMed PMID: 15229108. Full text (PDF)

29. Akimoto T, Sorg BS, Yan ZReal-time imaging of peroxisome proliferator-activated receptor-gamma coactivator-1alpha promoter activity in skeletal muscles of living mice. Am J Physiol Cell Physiol. 2004 Sep;287(3):C790-6. Epub 2004 May 19. PubMed PMID: 15151904. Full text (PDF)

28. Rosenberg P, Hawkins A, Stiber J, Shelton JM, Hutcheson K, Bassel-Duby R, Shin DM, Yan Z, Williams RS. TRPC3 channels confer cellular memory of recent neuromuscular activity. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9387-92. Epub 2004 Jun 15. PubMed PMID: 15199180; PubMed Central PMCID: PMC438986. Full text (PDF)

27. Rybkin II, Markham DW, Yan Z, Bassel-Duby R, Williams RS, Olson EN. Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation. J Biol Chem. 2003 May 2;278(18):15927-34. Epub 2003 Feb 17. PubMed PMID: 12590133. Full text (PDF)

26. Yan Z, Choi S, Liu X, Zhang M, Schageman JJ, Lee SY, Hart R, Lin L, Thurmond FA, Williams RS. Highly coordinated gene regulation in mouse skeletal muscle regeneration. J Biol Chem. 2003 Mar 7;278(10):8826-36. Epub 2002 Dec 10. PubMed PMID: 12477723. Full text (PDF)

25. Fraser I, Pearman T, William B, Sinkovits B, Dufford M, et al. Yeast two-hybrid interactions in B lymphocytes and cardiac myocytes. AfCS Research Reprot. 2003. Full text (PDF)

24. Sambrano GR, Fraser I, Han H, Ni Y, O'Connell T, Yan Z, Stull JT. Navigating the signalling network in mouse cardiac myocytes.Nature. 2002 Dec 12;420(6916):712-4. PubMed PMID: 12478303. Full text (PDF)

23. O'Connell TD, Ni Y, Lin KM, Han H, Yan Z. Isolation and culture of adult mouse cardiac myocytes for signaling studies. AfCS Research Reprot. 2002; 1(5):1-9. Full text (PDF)

22. Han H, Hsueh RC, Lin KM, O'Connell TD, Yan Z. Purification and characterization of mouse splenic B lymphocytes. AfCS Research Report. 2002; 1(1):1-11. Full text (PDF)

21. Yan Z, Serrano AL, Schiaffino S, Bassel-Duby R, Williams RS. Regulatory elements governing transcription in specialized myofiber subtypes. J Biol Chem. 2001 May 18;276(20):17361-6. Epub 2001 Feb 26. PubMed PMID: 11279187.Full text (PDF)

20. Garry DJ, Meeson A, Yan Z, Williams RS. Life without myoglobin. Cell Mol Life Sci. 2000 Jun;57(6):896-8. Review. PubMed PMID: 10950305.

19. Yan Z, Fedorov SA, Mumby MC, Williams RS. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Mol Cell Biol. 2000 Feb;20(3):1021-9. PubMed PMID: 10629059; PubMed Central PMCID: PMC85219. Full text (PDF) 

18. Yan ZSkeletal muscle adaptation and cell cycle regulation. Exerc Sport Sci Rev. 2000 Jan;28(1):24-6. Review. PubMed PMID: 11131685.

17. Yan Z, Booth FW. Cytochrome c promoter activity in soleus and white vastus lateralis muscles in rats. J Appl Physiol (1985). 1998 Sep;85(3):973-8. PubMed PMID: 9729572. Full text (PDF)  

16. Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams RS, Nevins JR. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev. 1998 Jul 15;12(14):2120-30. PubMed PMID: 9679057; PubMed Central PMCID: PMC317011. Full text (PDF)

15. Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3603-8. PubMed PMID: 9520412; PubMed Central PMCID: PMC19882. Full text (PDF) 

14. Booth FW, Lou W, Hamilton MT, Yan ZCytochrome c mRNA in skeletal muscles of immobilized limbs. J Appl Physiol (1985). 1996 Nov;81(5):1941-5. PubMed PMID: 8941513. Full text (PDF)  

13. Yan Z, Salmons S, Dang YI, Hamilton MT, Booth FW. Increased contractile activity decreases RNA-protein interaction in the 3'-UTR of cytochrome c mRNA. Am J Physiol. 1996 Oct;271(4 Pt 1):C1157-66. PubMed PMID: 8897821. Full text (PDF)

12. Booth FW, Carson JA, Yan Z. Biochemistry of Exercise IX. Maughan RJ, Shirreffs SM, editors. Champaign, IL: Human Kinetics; 1996. Molecular and cellular adaptations of muscle in response to exercise. 339-44p. 

11. Carson JA, Yan Z, Booth FW, Coleman ME, Schwartz RJ, Stump CS. Regulation of skeletal alpha-actin promoter in young chickens during hypertrophy caused by stretch overload. Am J Physiol. 1995 Apr;268(4 Pt 1):C918-24. PubMed PMID: 7537453. Full text (PDF)

10. Yan Z, Salmons S, Jarvis J, Booth FW. Increased muscle carnitine palmitoyltransferase II mRNA after increased contractile activity.Am J Physiol. 1995 Feb;268(2 Pt 1):E277-81. PubMed PMID: 7864104. Full text (PDF)  

9. Katz A, Yan ZPhosphofructokinase activity in human skeletal muscle: effects of euglycaemic hyperinsulinaemia and fasting.Scand J Clin Lab Invest. 1993 Dec;53(8):853-8. PubMed PMID: 8140396.

8. Yan Z, Spencer MK, Katz A. No effect of carbohydrate feeding on glycogen synthase in human muscle during exercise. Clin Physiol. 1993 May;13(3):265-70. PubMed PMID: 8519162.

7. Yan Z, Biggs RB, Booth FW. Insulin-like growth factor immunoreactivity increases in muscle after acute eccentric contractions. J Appl Physiol (1985). 1993 Jan;74(1):410-4. PubMed PMID: 8444721.Full text (PDF)

6. Yan Z, Spencer MK, Bechtel PJ, Katz A. Regulation of glycogen synthase in human muscle during isometric contraction and recovery. Acta Physiol Scand. 1993 Jan;147(1):77-83. PubMed PMID: 8452044.

5. Yan Z, Spencer MK, Katz A. Effect of low glycogen on glycogen synthase in human muscle during and after exercise. Acta Physiol Scand. 1992 Aug;145(4):345-52. PubMed PMID: 1529722.

4. Spencer MK, Yan Z, Katz A. Effect of low glycogen on carbohydrate and energy metabolism in human muscle during exercise. Am J Physiol. 1992 Apr;262(4 Pt 1):C975-9. PubMed PMID: 1566823. Full text (PDF)  

3. Castillo CE, Katz A, Spencer MK, Yan Z, Nyomba BL. Fasting inhibits insulin-mediated glycolysis and anaplerosis in human skeletal muscle. Am J Physiol. 1991 Nov;261(5 Pt 1):E598-605. PubMed PMID: 1951684. Full text (PDF) 

2. Katz A, Spencer MK, Lillioja S, Yan Z, Mott DM, Haller RG, Lewis SF. Basal and insulin-mediated carbohydrate metabolism in human muscle deficient in phosphofructokinase 1. Am J Physiol. 1991 Oct;261(4 Pt 1):E473-8. PubMed PMID: 1833982. Full text (PDF)

Reviews 
1. Yan Z. One more trick in the regulation of PGC-1α. Cell Science Reviews 6(2):88, 2009. Full text (PDF)

2. Li P and Yan Z. Skeletal muscle adaptation in response to exercise. Chin. J. Rehab. Med., 19:304-6&384-7, 2004.

3. Booth FW, Carson JA, and Yan Z. Molecular and cellular adaptations of muscle in response to exercise. Biochemistry of Exercise IX. R.J. Maughan and S.M. Shirreffs, eds., Human Kinetics: Champaign, IL; pp 339-344, 1996. 

4. Yan Z., Carson JA, and Booth FW. Applications of molecular biology to exercise physiology. The 5th International Course and Conference on Physiological Biochemistry and Nutrition of Exercise and Training. 1995.

Book Sections
1. Yan Z, Williams RS. Principles of Molecular Medicine . 2nd ed. Marschall SR, Patterson C, editors. Totowa, NJ: Humana Press; 2006. Skeletal muscle hypertrophy and response to training. 688-92p.

2. Booth FW, Carson JA, Yan Z. Biochemistry of Exercise IX. Maughan RJ, Shirreffs SM, editors. Champaign, IL: Human Kinetics; 1996. Molecular and cellular adaptations of muscle in response to exercise. 339-44p. 

"上醫治未病 Superior doctors prevent the disease, mediocre doctors treat the disease before evident, inferior doctors treat the full-blown disease."-----Huangdi Neijing (2600 BCE) First Chinese Medical Text