Yan Laboratory
Molecular
Exercise Physiology

Center for Skeletal Muscle Research
Robert M. Berne Cardiovascular Research Center
University of Virginia School of Medicine
409 Lane Road, MR4 - 6041A
Charlottesville, VA 22908
Phone: 434-982-4477
Fax: 434-982-3139
E-mail:
zhen.yan@virginia.edu

Publications


Peer-reviewed articles

1. Spencer MK, Yan Z, Katz A. Carbohydrate supplementation attenuates IMP accumulation in human muscle during prolonged exercise. Am J Physiol 1991; 261:C71-6. Full text (PDF)
2. Katz A, Spencer MK, Lillioja S, Yan Z, Mott DM, Haller RG, Lewis SF. Basal and insulin-mediated carbohydrate metabolism in human muscle deficient in phosphofructokinase 1. Am J Physiol 1991; 261:E473-8. Full text (PDF)
3. Castillo CE, Katz A, Spencer MK, Yan Z, Nyomba BL. Fasting inhibits insulin-mediated glycolysis and anaplerosis in human skeletal muscle. Am J Physiol 1991; 261:E598-605. Full text (PDF)
4. Spencer MK, Yan Z, Katz A. Effect of low glycogen on carbohydrate and energy metabolism in human muscle during exercise. Am J Physiol 1992; 262:C975-9. Full text (PDF) 
5. Yan Z, Spencer MK, Katz A. Effect of low glycogen on glycogen synthase in human muscle during and after exercise. Acta Physiol Scand 1992; 145:345-52. 
6. Yan Z, Spencer MK, Bechtel PJ, Katz A. Regulation of glycogen synthase in human muscle during isometric contraction and recovery. Acta Physiol Scand 1993; 147:77-83.
7. Yan Z, Biggs RB, Booth FW. Insulin-like growth factor immunoreactivity increases in muscle after acute eccentric contractions. J Appl Physiol 1993; 74:410-4. Full text (PDF) 
8. Yan Z, Spencer MK, Katz A. No effect of carbohydrate feeding on glycogen synthase in human muscle during exercise. Clin Physiol 1993; 13:265-70.
9. Katz A, Yan Z. Phosphofructokinase activity in human skeletal muscle: effects of euglycaemic hyperinsulinaemia and fasting. Scan J Clin Lab Invest 1993; 53:853-8.
10. Yan Z, Salmons S, Jarvis J, Booth FW. Increased muscle carnitine palmitoyltransferase II mRNA after increased contractile activity. Am J Physiol 1995; 268:E277-81. Full text (PDF) 
11. Carson JA, Yan Z, Booth FW, Coleman ME, Schwartz RJ, Stump CS. Regulation of skeletal alpha-actin promoter in young chickens during hypertrophy caused by stretch overload. Am J Physiol 1995; 268:C918-24. Full text (PDF)
12. Yan Z, Salmons S, Dang YL Hamilton MT, Booth FW. Increased contractile activity decreases RNA-protein interaction in the 3'-UTR of cytochrome c mRNA. Am J Physiol 1996; 271:C1157-66. Full text (PDF)
13. Booth FW, Lou W, Hamilton MT, Yan Z. Cytochrome c mRNA in skeletal muscles of immobilized limbs. J Appl Physiol 1996; 81:1941-5. Full text (PDF) 
14. Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc Natl Acad Sci 1998; 95:3603-8. Full text (PDF) 
15. Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams RS, Nevins JR. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes & Dev 1998; 12:2120-30. Full text (PDF)
16. Yan Z, Booth FW. Cytochrome c promoter activity in soleus and white vastus lateralis muscles in rats. J Appl Physiol 1998; 85:973-8. Full text (PDF) 
17. Yan Z, Fedorov SA, Mumby MC, Williams RS. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Mol & Cell Biol 2000; 20:1021-9. Full text (PDF)
18. Yan Z, Serrano AL, Schiaffino S, Bassel-Duby R, Williams RS. Regulatory elements governing transcription in specialized myofiber subtypes. J Biol Chem 2001; 276:17361-6. Full text (PDF)
19. Yan Z*, Choi S, Liu X, Zhang M, Schageman JJ, Lee SY, Hart R, Lin L, Thurmond FA, Williams RS. Highly coordinated gene regulation in mouse skeletal muscle regeneration. J Biol Chem 2002; 278(10):8826-36. Full text (PDF)
20. Han H, Hsueh RC, Lin KM, O’Connell TD, Yan Z. Purification and characterization of mouse splenic B lymphocytes. AfCS Research Reprot 2002; 1(1):1-11. Full text (PDF)
21. Sambrano GR, Fraser I, Han H, Ni Y, O'Connell T, Yan Z, Stull JT. Navigating the signaling network in mouse cardiac myocytes. Nature 2002; 420:712-714. Full text (PDF)
22. Rybkin II, Markham DW, Yan Z, Bassel-Duby R, Williams RS, Olson EN. Conditional expression of SV40 T antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation. J Biol.Chem 2003; 278(18):15927-34. Full text (PDF)
23. Fraser, I, Pearman T, Williams B, Sinkovits B, Dufford M, Lin KM, Hsueh RC, Yan Z, Grosssoehme J, Pierce R, Polasek J, Girouard J, Heichman K, Bartel P, Sambrano G. Yeast two-hybrid interactions in B lymphocytes and cardiac myocytes. AfCS Research Reprot 2003. Full text (PDF)
24. O’Connell TD, Ni Y, Lin KM, Han H and Yan Z. Isolation and culture of adult mouse cardiac myocytes for signaling studies. AfCS Research Reprot 2003; 1(5):1-9. Full text (PDF)
25. Akimoto T, Sorg BS, and Yan Z. Real-time imaging of peroxisome proliferator activated receptor γ co-activator-1α promoter activity in skeletal muscles of living mice. Am J Physiol 2004; 287(3):C790-6. Full text (PDF)
26. Rosenberg PB, Hawkins A, Stiber J, Shelton JM, Hutcheson K, Bassel-Duby R, Yan Z, Shin DM, and Williams RS. TRPC3 channels confer cellular memory of recent neuromuscular activity. Proc Natl Acad Sci 2004; 101(25):9387-92. Full text (PDF)
27. Akimoto T, Ribar TJ, Williams RS, and Yan Z. Skeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) deficient mice. Am J Physiol 2004; 287(5):C1311-9. Full text (PDF)
28. Waters RE, Rotevatn S, Li P, Annex BH, and Yan Z. Voluntary Running Induces Fiber Type-Specific Angiogenesis in Mouse Skeletal Muscle. Am J Physiol 2004; 287(5):C1342-8. Full text (PDF)
29. Zhu X, Hart R, Kim JW, Lee SY, Chang MS, Cao YA, Mock D, Ke E, Saunders B, Alexander A, Grossoehme J, Yan Z, Hsueh R, Fruman D, Subramaniam S, Sternweis P, Simon MI, Choi S. Analysis of the Major Patterns of B Cell Gene Expression Changes in Response to Short-Term Stimulation with 33 Single Ligands. Journal of Immunology 2004; 173(12):7141-9. Full text (PDF)
30. Akimoto T, Ushida T, Miyaki S, Akaogi H, Tsuchiya K, Yan Z, Williams RS, Tateishi T. Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling. Biochem Biophys Res Commun 2005; 329(1):381-5. Full text (PDF)
31. Akimoto T, Pohnert SC, Li P, Zhang M, Gumbs C, Rosenberg PB, Williams RS, Yan Z. Exercise stimulates PGC-1α transcription in skeletal muscle through activation of the p38 MAPK pathway. J. Biol. Chem. 2005; 280(20):19587-93. Full text (PDF)
32. Koves TR, Li P, Akimoto T, An J, Slentz D, Ilkayeva O, Dohm GL, Yan Z, Newgard CB, Muoio DM. PGC-1α-mediated metabolic remodeling of skeletal muscle mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J. Biol. Chem. 2005; 280(39):33588-98. Full text (PDF)
33. Choi S, Liu X, Li P, Akimoto T, Lee SY, Gumbs C, Zhang M, Yan Z. Transcriptional profiling in mouse skeletal muscle following a single bout of voluntary running: evidence of increased cell proliferation. J. Appl. Physiol. 99(6):2406-15, 2005. Full text (PDF)
34. Li P, Akimoto T, Zhang M, Williams RS, Yan Z.  Resident stem cells are not required for exercise-induced fiber type-switching and angiogenesis, but required for activity-dependent muscle growth. Am. J. Physiol. 2006; 290(6):C1461-8. Full text (PDF)
35. Perrino C, Prasad SV, Mao L, Noma T, Yan Z, Kim HS, Smithies O, Rockman HA. Intermittent overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. J. Clin. Invest. 2006; 116(6):1547-6. Full text (PDF)
36.
Li P, Waters RE, Redfern SI, Zhang M, Mao L, Annex BH, Yan Z. Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice. Am. J. Pathol. 2007; 170(2):599-608. Full text (PDF)
37. Jeftinija DM, Hebert SL, Norris CM, Wang QB, Yan Z, Rich MM, and Kraner SD. The CaV 1.2 Ca2+ channel is expressed in the sarcolemma of type I and IIa skeletal muscle fibers. Muscle & Nerve 2007; 36(4):482-90. Full text (PDF)
38. Handschin C, Chin S, Li P, Liu F, Maratos-Flier E, LeBrasseur NK, Yan Z, Spiegelman BM, Skeletal muscle fiber-type switching, exercise intolerance and myopathy in PGC-1? muscle-specific knockout animals, J. Biol. Chem 2007; 282(41):30014-21. Full text (PDF)
39. Wooldridge AA, Fortner CN, Lontay B, Akimoto T, Neppl RL, Facemire C, Datto MB, Kwon A, McCook E, Li P, Wang S, Thresher RJ, Miller SE, Perriard JC, Gavin TP, Hickner RC, Coffman TM, Somlyo AV, Yan Z, Haystead TA. Deletion of the PKA/PKG target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. J. Biol. Chem 283:11850-9, 2008. Full text (PDF)
40. Davis AJ, Yan Z, Mumby MC. Calcium regulates targeting of PP2A to Cdc6 via the PR70 subunit. J Biol Chem 283:16104-14, 2008. Full text (PDF)
41. Yu Z, Li P, Zhang M, Hannink M, Stamler JS, Yan Z. Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli. PLoS One 3(5): e2086, 2008. Full text (PDF)
42. Akimoto T, Li P, Yan Z. Functional interaction of regulatory factors with the Pgc-1? promoter in response to exercise by in vivo imaging. Am. J. Physiol. Cell Physiol 295(1):C288-92, 2008. Full text (PDF)
43. Sun B, Youngi SP, Li P, Di C, Brown T, Salva MZ, Li S, Bird A, Yan Z, Auten R, Hauschka SD, Koeberl DD. Correction of Multiple Striated Muscles in Murine Pompe Disease Through Adenoassociated Virus-Mediated Gene Therapy. Mol Therapy 16:1366-71, 2008. Full text (PDF)
44. Ajijola OA, Dong C, Herderick E, Qi Ma, Goldschmidt-Clermont PJ, Yan Z. Voluntary running suppresses pro-inflammatory cytokines and bone marrow endothelial progenitor cell levels in Apolipoprotein E-deficient mice. Antioxid Redox Signal 11:15-23, 2008. Full text (PDF)
45. Hazarika S, Angelo M, Li Y, Aldrich AJ, Odronic S, Yan Z, Stamler JS, Annex BH. Myocyte Specific Overexpression of Myoglobin Impairs Angiogenesis Following Hind-limb Ischemia. Arterioschlerosis, Thrombosis, and Vascular Biology 28:2144-50, 2008. Full text (PDF)
46. Pogozelski1 AR, Geng T, Li P, Yi X1, . Lira VA, Zhang M, Chi J, Yan Z. p38γ mitogen-activated protein kinase is a key regulator in skeletal suscle metabolic adaptation in mice. PLoS One 4(11): e7934, 2009. Full text (PDF)
47. McClung JM, Judge AR, Powers SK, Yan Z. p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting. Am J Physiol Cell Physiol. 2010, 298(3):C542-9, PMCID: PMC2838571 link
48. Geng T, Li P, Okutsu M, Yin X, Kwek J, Zhang M, Yan Z. PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. Am J Physiol Cell Physiol. 2010, 298(3):C572-9, PMID: 20032509 link
49. Chen JF, Tao Y, Li J, Deng Z, Yan Z, Xiao X, Wang DZ. microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. J Cell Biol. 2010 Sep 6;190(5):867-79. PubMed PMID: 20819939; PubMed Central PMCID: PMC2935565.
50. Huang P, Li S, Shao M, Qi Q, Zhao F, You J, Mao T, Li W, Yan Z*, Liu Y*. Calorie restriction and exercise training share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice, Nutr Metab (Lond). 2010, 7(1):59. [Epub ahead of print] (*Corresponding authors) link
51. Zechner C, Lai L, Zechner JF, Geng T, Yan Z, Rumsey JW, Collia D, Chen Z, Wozniak DF, Leone TC, Kelly DP. Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. Cell Metab. 2010 Dec 1;12(6):633-42. PubMed PMID: 21109195; PubMed Central PMCID: PMC2999961.
52. Geng T, Li P, Yin X, Yan Z. PGC-1α Promotes Nitric Oxide Antioxidant Defenses and Inhibits FOXO Signaling Against Cardiac Cachexia in Mice. Am J Pathol. 2011 Apr;178(4):1738-48. PubMed PMID: 21435455. Link
53. Gagan J, Dey BK, Layer R, Yan Z, Dutta A. MICRORNA-378 targets the myogenic repressor myor during myoblast differentiation. J Biol Chem. 2011 Apr 6. [Epub ahead of print] PubMed PMID: 21471220. Link
54. Wada S, Kato Y, Okutsu M, Miyaki S, Suzuki K, Yan Z, Schiaffino S, Asahara H, Ushida T, Akimoto T. Translational suppression of atrophic regulators by miR-23a integrates resistance to skeletal muscle atrophy. J Biol Chem. 2011 Sep 18. [Epub ahead of print] PubMed PMID: 21926429. Link
55. Griffin TM, Huebner J, Kraus VB, Yan Z, Guilak F. Effects of Voluntary Running on Osteoarthritis Progression and Inflammation in High-Fat Diet-induced Obese Mice. Arthritis Rheum. 2011 Sep 27. doi: 10.1002/art.33332. [Epub ahead of print] PubMed PMID: 21953366. Link
56. Meher AK, Sharma PR, Lira VA, Yamamoto M, Kensler TW, Yan Z, Leitinger N. Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance. Free Radic Biol Med. 2012 Feb 24;52(9):1708-1715. Link
57. Baltgalvis KA, Call JA, Cochrane GD, Laker RC, Yan Z, Lowe DA. Exercise Training Improves Plantarflexor Muscle Function in mdx Mice. Med Sci Sports Exerc. 2012 Mar 28. [Epub ahead of print] PMID: 22460476 Link
58. Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.Proc Natl Acad Sci U S A. 2012 Apr 9. [Epub ahead of print] PMID: 22493257 Link
59. Zhou B, Yang L, Li S, Huang J, Chen H, Hou L, Wang J, Green CD, Yan Z, Huang X, Kaeberlein M, Zhu L, Xiao H, Liu Y, Han JD. Midlife gene expressions identify modulators of aging through dietary interventions. Proc Natl Acad Sci U S A. 2012 May 8;109(19):E1201-9. Link
60. Dey BK, Gagan J, Yan Z, Dutta A. miR-26a is required for skeletal muscle differentiation and regeneration in mice. Genes Dev. 2012 Oct 1;26(19):2180-91. Link
61. Gagan J, Dey BK, Layer R, Yan Z, Dutta A. Notch3 and Mef2c Are Mutually Antagonistic via Mkp1 and miR-1/206 in Differentiating Myoblasts. J Biol Chem. 2012 Oct 10. Link
62. Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM. A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy. Cell. 2012 Dec 7;151(6):1319-31. doi: 10.1016/j.cell.2012.10.050. PubMed PMID: 23217713; PubMed Central PMCID: PMC3520615. Link
63. Zhang C, Li S, Yang L, Huang P, Li W, Wang S, Zhao G, Zhang M, Pang X, Yan Z, Liu Y, Zhao L. Structural modulation of gut microbiota in life-long calorie-restricted mice. Nat Commun. 2013;4:2163. PubMed PMID: 23860099; PubMed Central PMCID: PMC3717500. Link
64. Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Jung DY, Okutsu M, Yan Z, Kim JK, Lin JD. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nat Med. 2013 May;19(5):640-5. Link
65. Hochreiter-Hufford AE, Lee CS, Kinchen JM, Sokolowski JD, Arandjelovic S, Call JA, Klibanov AL, Yan Z, Mandell JW, Ravichandran KS. Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature. 2013 May 9;497(7448):263-7. Link
66. Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P, Arany Z. Disconnecting Mitochondrial Content from Respiratory Chain Capacity in PGC-1-Deficient Skeletal Muscle. Cell Rep. 2013 May 30;3(5):1449-56.
Link
67. Zhang C, He Y, Okutsu M, Ong LC, Jin Y, Zheng L, Chow P, Yu S, Zhang M, Yan Z. Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation. Am J Physiol Endocrinol Metab. 2013 Aug 15;305(4):E530-9. PubMed PMID: 23800883.
68. Katwal AB, Konkalmatt PR, Piras BA, Hazarika S, Li SS, John Lye R, Sanders JM, Ferrante EA, Yan Z, Annex BH, French BA. Adeno-associated virus serotype 9 efficiently targets ischemic skeletal muscle following systemic delivery. Gene Ther. 2013 Mar 28. Link
69. Lira VA, Okutsu M, Zhang M. Greene NP, Laker RC,Breen DS, Hoehn KL, Yan Z. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. FASEB J. 2013 Oct;27(10):4184-93. NEWSPLEX.COM, 1070 WINA, UVA Health System, UVAToday, Majori Drugs.
70. Laker RC, Lillard T, Okutsu M, Zhang M, Hoehn LK, Connelly JJ and Yan Z. Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes. 2014 Jan 15. [Epub ahead of print] PMID: 24430439. Augusta Free Press, PRWeb, UVa Health, Digital Journal, NBC29, UVAToday, UVA Connect, Futurity, Amwayhealthline, kesehatan ibu dan anak, CavalierDaily, Vitals,
71. Okutsu M, Call JA, Lira VA, Zhang M, Donet JA, French BA, Martin KS, Peirce-Cottler SM, Rembold CM, Annex BH, Yan Z. Extracellular Superoxide Dismutase Ameliorates Skeletal Muscle Abnormalities, Cachexia and Exercise Intolerance in Mice with Congestive Heart Failure. Circ Heart Fail. 2014 Feb 12. [Epub ahead of print] PubMed PMID: 24523418 ."Current Editor's Picks", Pubz,
72. Hindi SM, Mishra V, Bhatnagar S, Tajrishi MM, Ogura Y, Yan Z, Burkly LC, Zheng TS, Kumar A. Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program. FASEB J. 2013 Dec 10. [Epub ahead of print] PubMed PMID: 24327607.
73.
Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Harris TE, Keller SR, Chow JD, Lynch KR, Chokki M, Molkentin JD, Turner N, James DE, Yan Z, Hoehn KL. Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Mol Metab. 2014 Apr;3(2):124-34. doi: 10.1016/j.molmet.2013.11.003. PubMed PMID: 24634818.
74. Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab. 2014 Apr;3(2):114-23. doi: 10.1016/j.molmet.2013.11.005. PubMed PMID: 24634817.
75. Laker RC, Xu P, Ryall KA, Sujkowski A, Kenwood BM, Chain KH, Zhang M, Royal MA, Hoehn KL, Dirscoll M, Adler PN, Wessells RJ, Saucerman JJ, Yan Z. A novel MitoTimer reporter gene for mitochondrial content, structure, stress and damage in vivo. J Biol Chem. 2014 Mar 18. [Epub ahead of print] PubMed PMID: 24644293.
76. Lee HY, Gattu AK, Camporez JP, Kanda S, Guigni B, Kahn M, Zhang D, Galbo T, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Choi CS, Yan Z, Williams RS, Shulman GI, Samuel VT. Muscle-specific activation of Ca2+/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia. 2014 Apr 11. [Epub ahead of print] PubMed PMID: 24718953.
77. Call JA, Chain KH, Martin KS, Lira VA, Okutsu M, Zhang M, Yan Z. Enhanced Skeletal Muscle Expression of EcSOD Mitigates Streptozotocin-Induced Diabetic Cardiomyopathy by Reducing Oxidative Stress and Aberrant Cell Signaling. Circ Heart Fail. 2014 PubMed PMID: 25504759.UVAToday, NBC29, EurekAlert, Augusta Free Press, MyInforms.com, A1Parkistan, EndocrinologyAdvisor, CommonHealth, Me vs. Diabetes, MDLinx, Fitness Seed, MassLegalServices, BrightSurf.com, MedicalXpress, ScienceDaily, UVA Health,
78. Chao H, Li H, Grande R, Lira V, Yan Z, Harris T, Li C. Involvement of mTOR in type 2 CRF receptor inhibition of insulin signaling in muscle cells. Mol Endocrinol. 2015 Apr 15:me20141245. [Epub ahead of print] PubMed PMID: 25875045.
79. Drake JC, Wilson RJ, Yan Z. Molecular mechanisms for mitochondrial adaptation to exercise training in skeletal muscle. FASEB J. 2015. PubMed PMID: 26370848.
80. Klionsky DJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. PubMed PMID: 26799652.
81. Laker RC, Taddeo EP, Akhtar YN, Zhang M, Hoehn KL, Yan Z. The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis. PLoS One. 2016 Dec 22;11(12):e0167910; PubMed Central PMCID: PMC5179060.
82. Forrester SJ, Elliott KJ, Kawai T, Obama T, Boyer MJ, Preston KJ, Yan Z, Eguchi S, Rizzo V. Caveolin-1 Deletion Prevents Hypertensive Vascular Remodeling Induced by Angiotensin II. Hypertension. 2017 Jan;69(1):79-86. PubMed PMID: 27895190; PubMed Central PMCID: PMC5145768.
83. Leitner LM, Wilson RJ, Yan Z, Gödecke A. Reactive Oxygen Species/Nitric Oxide Mediated Inter-Organ Communication in Skeletal Muscle Wasting Diseases. Antioxid Redox Signal. 2017 Jan 4; PubMed PMID: 27835923.
84. Call JA, Wilson RJ, Laker RC, Zhang M, Kundu M, Yan Z. Ulk1-mediated autophagy plays an essential role in mitochondrial remodeling and functional regeneration of skeletal muscle. Am J Physiol Cell Physiol. 2017 Mar 29; PubMed PMID: 28356270.
85. Taddeo EP, Hargett SR, Lahiri S, Nelson ME, Liao JA, Li C, Slack-Davis JK, Tomsig JL, Lynch KR, Yan Z, Harris TE, Hoehn KL. Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3. Sci Rep. 2017 Dec;7(1):127. PubMed PMID: 28273928.
86. Laker RC, Drake JC, Wilson RJ, Lira VA, Lewellen BM, Ryall KA, Fisher CC, Zhang M, Saucerman JJ, Goodyear LJ, Kundu M, Yan Z. Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy. Nat Commun (accepted)
87. Yan Z, Kronemberger A, Blomme J, Call JA, Caster HM, Pereira RO, Zhao H, de Melo VU, Laker RC, Zhang M, Lira VA. Exercise leads to unfavourable cardiac remodelling and enhanced metabolic homeostasis in obese mice with cardiac and skeletal muscle autophagy deficiency. Sci Rep. 2017 Aug 11;7(1)7894
88. Laker RC, Drake JC, Wilson RJ, Lira VA, Lewellen BM, Ryall KA, Fisher CC, Zhang M, Saucerman JJ, Goodyear LJ, Kundu M, Yan Z. Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy. Nat Commun 2017, 8(548)
89. Keller AS, Diederich L, Panknin C, DeLalio LJ, Drake JC, Sherman R, Jackson EK, Yan Z, Kelm M, Cortese-Krott MM, Isakson BE. Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway. Am J Physiol Cell Physiol. 2017 Aug 30:ajpcell.00178.2017. doi: 10.1152/ajpcell.00178.2017. [Epub ahead of print] PubMed PMID: 28855161.
90. Call JA, Donet J, Martin KS, Sharma AK, Chen X, Zhang J, Cai J, Galarreta CA, Okutsu M, Du Z, Lira VA, Zhang M, Mehrad B, Annex BH, Klibanov AL, Bowler RP, Laubach VE, Peirce SM, Yan Z. Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice. Free Radic Biol Med. 2017 Oct 2. pii: S0891-5849(17)30782-7. PubMed PMID: 28982599.

Reviews

1. Yan Z., Carson JA, and Booth FW. Applications of molecular biology to exercise physiology. The 5th International Course and Conference on Physiological Biochemistry and Nutrition of Exercise and Training. 1995.
2. Booth FW, Carson JA, and Yan Z. Molecular and cellular adaptations of muscle in response to exercise. Biochemistry of Exercise IX. R.J. Maughan and S.M. Shirreffs, eds., Human Kinetics: Champaign, IL; pp 339-344, 1996.
3. Yan Z . Muscle adaptation and cell cycle regulation. Exercise and Sport Sciences Reviews, 28(1):24-26, 2000.
4. Garry DJ, Meeson A, Yan Z, and Williams RS. Life without myoglobin. Cell. & Mol. Life Sci., 57(6):896-8, 2000.
5. Li P and Yan Z. Skeletal muscle adaptation in response to exercise. Chin. J. Rehab. Med., 19:304-6&384-7, 2004.
6. Yan Z, Li P, and Akimoto T. Transcriptional control of the Pgc-1α gene in skeletal muscle. Exerc Sport Sci Rev 35(3):97-101, 2007.
7. Yan Z. Exercise, PGC-1α and metabolic adaptation in skeletal muscle. Appl Physiol Nutr Metab 34(3):424-7, 2009. Full text (PDF)
8. Yan Z. One more trick in the regulation of PGC-1α. Cell Science Reviews 6(2):88, 2009. Full text (PDF)
9. Lira V, Benton CR, Yan Z, Bonen A, PGC-1a regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E145-61. PubMed PMID: 20371735; PubMed Central PMCID: PMC2928513. Full text (PDF)
10. Yan Z, Okutsu M, Akhtar YN, Lira VA. Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol (1985). 2011 Jan;110(1):264-74. PubMed PMID: 21030673.Link
11. Yan Z, Lira VA, Greene NP. Exercise training-induced regulation of mitochondrial quality. Exerc Sport Sci Rev. 2012 Jul;40(3):159-64. Link
12.
Booth FW, Ruegsegger GN, Toedebusch RG, Yan Z. Endurance Exercise and the Regulation of Skeletal Muscle Metabolism. Prog Mol Biol Transl Sci. 2015;135:129-51. Epub 2015 Sep 5. PubMed PMID: 26477913.
13. Drake JC, Yan Z. Mitophagy in skeletal muscle in maintaining mitochondrial proteostasis and metabolic health with aging. J Physiol (accepted)

Book Sections

1. Booth FW, Carson JA, Yan Z. Biochemistry of Exercise IX. Maughan RJ, Shirreffs SM, editors. Champaign, IL: Human Kinetics; 1996. Molecular and cellular adaptations of muscle in response to exercise. 339-44p.
2. Yan Z, Williams RS. Principles of Molecular Medicine . 2nd ed. Marschall SR, Patterson C, editors. Totowa, NJ: Humana Press; 2006. Skeletal muscle hypertrophy and response to training. 688-92p.