Yan Lab received funding from NIH to use machine learning and CRISPR/Cas9-mediated gene editing to investigate the moledular transducer of physical activity by joining Molecular Transducer of Physical Activity Consortium (MoTrPAC)

New Finding

We have discovered that endurance exercise training prevents onset of Freidrich's ataxia in mice along with improved mitochondrial function and reduced oxidative stress. The findings paved the way for clinical studies of the impact of endurance exercise in Freidrich's ataxia patients (Scientific Reports on Mar. 9, 2020)

New Member

Celeste Costa is a second-year undergraduate student at UVA majoring in chemistry, who is interested in how exercsie can prevent and treat diseases.

Welcome, Celeste!!

New Method

We have invented a voluntary weightlifting model in mice, which promotes muscle adaptation and insulin sensitivity with simultaneous enhancement of autophagy and mTOR pathway (FASEB Journal on Mar. 5, 2020)

"上醫治未病 Superior doctors prevent the disease, mediocre doctors treat the disease before evident, inferior doctors treat the full-blown disease."-----Huangdi Neijing (2600 BCE) First Chinese Medical Text